Results 51 to 60 of about 362,507 (292)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Lightweight Neural Network for Centroid Detection of Weak, Small Infrared Targets via Background Matching in Complex Scenes

Remote Sensing
In applications such as aerial object interception and ballistic estimation, it is crucial to precisely detect the centroid position of the target rather than to merely identify the position of the target bounding box or segment all pixels belonging to ...
Xiangdong Xu, Jiarong Wang, Zhichao Sha, Haitao Nie, Ming Zhu, Yu Nie   +5 more
doaj   +1 more source

Marriage of matching doors: Marital sorting on parental background in China

Demographic Research, 2016
Background: Who marries whom has important implications for the (re-)production of social inequalities. Whereas previous studies on marital sorting have mainly focused on the husband's and the wife's traits, in this research I assess the importance of ...
Yang Hu
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Topological distance-constrained feature descriptor learning model for vessel matching in coronary angiographies

Virtual Reality & Intelligent Hardware, 2021
Background: Feature matching technology is vital to establish the association between virtual and real objects in virtual reality and augmented reality systems. Specifically, it provides them with the ability to match a dynamic scene. Many image matching
Xiaojiao Song, Jianjun Zhu, Jingfan Fan, Danni Ai, Jian Yang   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Cost Effective Base-Matching Assay with Low Backgrounds [PDF]

Nucleic Acids Research, 1996
Base-matching or so-called mini-sequencing is a powerful technique for genotyping and mutation identification. However, its application is often hampered by high background and high cost. We have decreased the background by approximately 5-fold by incorporating an end-blocking step and using only 1/10 of the usual nucleotide concentrations.
X, Su, G, Mushinsky, A M, Comeau
openaire   +2 more sources

An evaluation of the performance of three semantic background knowledge sources in comparative anatomy

, 2010
In this paper we evaluate the performance and usefulness of three semantic background knowledge sources for predicting synonymous anatomical terms across species boundaries.
Ophuizen, E.A.A., van, Leunissen, J.A.M., Leunissen Jack A.M., Ophuizen Ernest A.A. van   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source