Results 41 to 50 of about 52,461 (230)
Estudo da influência da relação S0/X0 na determinação da atividade específica de bactérias nitrificantes [PDF]
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Química.Nos processos de remoção biológica de nitrogênio, a etapa de nitrificação, que consiste na oxidação do amônio a nitrato ...
Ferretti, Estela Cláudia
core
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
O presente estudo objetivou investigar se uma sequência didática com experimentação investigativa e foco no ensino do conteúdo de bactérias oferece caminhos para o desenvolvimento da Alfabetização Científica em uma turma do 6° ano do Ensino Fundamental ...
Adrielly Aparecida de Oliveira +3 more
doaj +1 more source
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
O escopo desta revisão foi abordar os principais aspectos da piodermite canina, enfatizando a importância da mesma na clínica médica de pequenos animais bem como na saúde pública.
Isael de Sousa Sá +10 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
<p align="justify"> O presente trabalho teve como objetivo avaliar a atividade antimicrobiana, in vitro, dos óleos essenciais extraÃdos de Lippia alba (Mill) N. E. Brown e Ocimum basilicum frente a microrganismos isolados de carnes bovinas. Os óleos foram extraÃdos por hidrodestilação e caracterizados quanto à composição por cromatograï¬
G. G. SANTOS +7 more
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source

