Results 121 to 130 of about 4,344,868 (378)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
BacteriaFungal infections significantly threaten public health, and many strains are resistant to antifungal drugs. Marine Actinobacteria have been identified as the generators of powerful bioactive compounds with antifungal activity and can be used to address ...
Nesrine Boublenza +4 more
doaj +1 more source
Rapid (<5 min) identification of pathogen in human blood by electrokinetic concentration and surface-enhanced Raman spectroscopy. [PDF]
, 2013 This study reports a novel microfluidic platform for rapid and long-ranged concentration of rare-pathogen from human blood for subsequent on-chip surface-enhanced Raman spectroscopy (SERS) identification/discrimination of bacteria based on their detected
Chang, Hsien-Chang +4 more
core
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
BacteriaBackground: Bacterial infections constitute a large portion of infectious disorders. The location of culture-positive specimens and profiles of antibiotic resistance for common pathogens have been the focal points of subsequent investigations ...
Mulat Erkihun +17 more
doaj +1 more source
Dissipative Shocks behind Bacteria Gliding
, 2014 Gliding is a means of locomotion on rigid substrates utilized by a number of bacteria includingmyxobacteria and cyanobacteria. One of the hypotheses advanced to explain this motility mechanism hinges on the role played by the slime filaments continuously
Virga, Epifanio G.
core +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Utilizing Plant Growth-Promoting Rhizobacteria (PGPR) to Advance Sustainable Agriculture
BacteriaPlant growth-promoting rhizobacteria (PGPR) are beneficial bacteria that play a crucial role in sustainable agriculture by enhancing plant growth through various mechanisms.
Piao Yang +5 more
doaj +1 more source
The immune response to Prevotella bacteria in chronic inflammatory disease.
Immunology, 2017 The microbiota plays a central role in human health and disease by shaping immune development, immune responses and metabolism, and by protecting from invading pathogens.
J. M. Larsen
semanticscholar +1 more source