Catch-bond mechanism of the bacterial adhesin FimH [PDF]
Nature Communications, 2016 Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between
Maximilian M. Sauer +9 more
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Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation [PDF]
mBio, 2021 Bacterial adhesins are key virulence factors that are essential for the pathogen-host interaction and biofilm formation that cause most infections. Many of the adhesin-driven cell-cell interactions are mediated by lectins.
Shuaiqi Guo +7 more
doaj +2 more sources
Discovery of fibrillar adhesins across bacterial species [PDF]
BMC Genomics, 2021 Background Fibrillar adhesins are long multidomain proteins that form filamentous structures at the cell surface of bacteria. They are an important yet understudied class of proteins composed of adhesive and stalk domains that mediate interactions of ...
Vivian Monzon +2 more
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Platelets, Bacterial Adhesins and the Pneumococcus [PDF]
Cells, 2022 Systemic infections with pathogenic or facultative pathogenic bacteria are associated with activation and aggregation of platelets leading to thrombocytopenia and activation of the clotting system. Bacterial proteins leading to platelet activation and aggregation have been identified, and while platelet receptors are recognized, induced signal ...
Kristin Jahn +4 more
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The 32 kDa Outer Membrane Proteins of Klebsiella pneumoniae Acts as A Bacterial Adhesin
Jurnal Ilmu Dasar, 2022 Klebsiella pneumoniae is a bacterium that often causes infection in the human body. At present K. pneumoniae can resist some of the antibiotics it has associated with modification of one of the virulence factors possessed by K. pneumoniae.
Dini Agustina +5 more
doaj +3 more sources
Role of Hydration in Collagen Recognition by Bacterial Adhesins [PDF]
Biophysical Journal, 2011 Protein-protein recognition regulates the vast majority of physiological or pathological processes. We investigated the role of hydration in collagen recognition by bacterial adhesin CNA by means of first principle molecular-dynamics samplings. Our characterization of the hydration properties of the isolated partners highlights dewetting-prone areas on
Luigi Vitagliano +2 more
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Identification of Tp0751 (Pallilysin) as a Treponema pallidum Vascular Adhesin by Heterologous Expression in the Lyme disease Spirochete [PDF]
Scientific Reports, 2017 Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body.
Wei-Chien Andrew Kao +12 more
doaj +2 more sources
Structure and functional analysis of a bacterial adhesin sugar-binding domain. [PDF]
PLoS ONE, 2019 Bacterial adhesins attach their hosts to surfaces through one or more ligand-binding domains. In RTX adhesins, which are localized to the outer membrane of many Gram-negative bacteria via the type I secretion system, we see several examples of a putative
Tyler D R Vance +4 more
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Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery. [PDF]
J Biol Chem, 2019 Spencer C +3 more
europepmc +3 more sources
Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system. [PDF]
J Biol Chem, 2018 Rabbani S +7 more
europepmc +3 more sources