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Evolution and structural dynamics of bacterial glycan binding adhesins
Current Opinion in Structural Biology, 2017Infectious disease processes like bacterial adherence or the activity of secreted toxins frequently gain host and tissue specificity by glycan binding interactions with the host glycome. Recent functional and structural studies highlight the high niche specialization of bacterial lectins, but also reveal a remarkable plasticity in their glycan binding ...
Kristof, Moonens, Han, Remaut
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Chapter 25. Bacterial Adhesins
1991Publisher Summary Adhesins are proteins located on the surface of the bacteria that mediate their attachment to specific substrates as a prelude to colonization. Substrates may be inanimate surfaces, eukaryotic cells, or other bacteria. The relatively specific nature of adhesin interactions differentiates their mode of action from other surface ...
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Bacterial Adhesins: Determinants of Microbial Colonization and Pathogenicity
Advances in Pediatrics, 1997Bacterial adhesins are a critical determinant of microbial colonization and are fundamental to disease pathogenesis. In this chapter, I have reviewed certain paradigms that exist with respect to structure, variation of expression, and biologic activity.
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Gonococcal lipooligosaccharide: an adhesin for bacterial dissemination? Response
Trends in Microbiology, 2000Dr Nassif discusses gonococcal lipooligosaccharide (LOS) and its role as an adhesin in bacterial dissemination. Our laboratory has shown that, in HepG2 cells and sperm cells, the terminal lactosamine present on lacto-N-neotetraose-terminal gonococcal LOS is a ligand for the human asialoglycoprotein receptor (ASGP-R) 1.xNeisseria gonorrhoeae utilizes ...
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Relationship Between Bacterial Cell Surfaces and Adhesins
1994The central dogma of bacterial adhesion requires that the adhesin(s) function from the bacterial surface. In most cases, the adhesins are assembled on the surface, but in a few cases, the adhesins are initially secreted in the soluble form and then associate with the bacterial surface (Tuomanen, 1986; Baker et al., 1991; Wentworth et al., 1991).
Itzhak Ofek, Ronald J. Doyle
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Characterization of Lectins and Bacterial Adhesins in Activated Sludge Flocs
Proceedings of the Water Environment Federation, 2008Bacterial lectins are carbohydrate‐binding proteins that are involved in bacterial adhesion and aggregation. To investigate whether lectins are involved in floc formation of activated sludge, hemaaggultination (HA) and HA inhibition assays were conducted on extracellular polymeric substances (EPS) extracted from activated sludges. Six sludges from both
Park, C, Novak, JT
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The Application of NMR Techniques to Bacterial Adhesins
2011Extracellular adhesins frequently compose large, highly-ordered structural assemblies that project away from the bacterial surface. These assemblies, known as pili or fimbriae, are rod-like polymeric structures that in some cases can extend up to several micrometers from the cell surface.
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Carbohydrates as recognition molecules for bacterial adhesins: Methodology and characteristics
Archives of Oral Biology, 1990Future attempts at developing inhibitors of dental plaque formation necessitate characterization of the bacterial-host, as well as the inter-bacterial recognition processes. Bacterial binding to a panel of solid-phase reference glycolipids was used to reveal the recognition of internal receptor sequences, low-affinity cooperative interactions, and ...
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