Results 21 to 30 of about 43,367 (250)

Bacterial Adhesins in Host-Microbe Interactions [PDF]

Cell Host & Microbe, 2009
Most commensal and pathogenic bacteria interacting with eukaryotic hosts express adhesive molecules on their surfaces that promote interaction with host cell receptors or with soluble macromolecules. Even though bacterial attachment to epithelial cells may be beneficial for bacterial colonization, adhesion may come at a cost because bacterial ...
Kline, Kimberly A., Fälker, Stefan, Dahlberg, Sofia, Normark, Staffan, Henriques-Normark, Birgitta   +4 more
openaire   +2 more sources

Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model [PDF]

, 2019
Background: Campylobacter jejuni infections constitute serious threats to human health with increasing prevalences worldwide. Our knowledge regarding the molecular mechanisms underlying host-pathogen interactions is still limited.
Backert, Steffen, Bereswill, Stefan, Boehm, Manja, Escher, Ulrike, Heimesaat, Markus M., Mousavi, Soraya, Schmidt, Anna-Maria, Tegtmeyer, Nicole   +7 more
core   +4 more sources

Adhesins as Targets for Vaccine Development

Emerging Infectious Diseases, 1999
Blocking the primary stages of infection, namely bacterial attachment to host cell receptors and colonization of the mucosal surface, may be the most effective strategy to prevent bacterial infections. Bacterial attachment usually involves an interaction
Theresa M. Wizemann, John E. Adamou, Solomon Langermann   +2 more
doaj   +1 more source

Comparative proteomics of uropathogenic Escherichia coli during growth in human urine identify UCA-like (UCL) fimbriae as an adherence factor involved in biofilm formation and binding to uroepithelial cells [PDF]

, 2015
Uropathogenic Escherichia coli (UPEC) are the primary cause of urinary tract infection (UTI) in humans. For the successful colonisation of the human urinary tract, UPEC employ a diverse collection of secreted or surface-exposed virulence factors ...
Allsopp, LP, Moriel, DG, Schembri, MA, Totsika, M, Webb, RI, Wurpel, DJ   +5 more
core   +1 more source

Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen

The Cell Surface, 2019
We set out to develop scalable assays to measure bacterial adhesion to mammalian extracellular matrix proteins, with the aim to perform high-throughput screening for inhibitors.
Athanasios Saragliadis, Dirk Linke
doaj   +1 more source

Dynamic interactions of a conserved enterotoxigenic Escherichia coli adhesin with intestinal mucins govern epithelium engagement and toxin delivery [PDF]

, 2016
At present, there is no vaccine for enterotoxigenic Escherichia coli (ETEC), an important cause of diarrheal illness. Nevertheless, recent microbial pathogenesis studies have identified a number of molecules produced by ETEC that contribute to its ...
Bhullar, Kirandeep, Fleckenstein, James M, Kuhlmann, F. Matthew, Kumar, Pardeep, Luo, Qingwei, Vallance, Bruce A, Xia, Lijun, Yang, Hyungjun   +7 more
core   +2 more sources

Bacterial adhesins: function and structure

International Journal of Medical Microbiology, 2000
Specific adhesion to host tissue cells is an essential virulence factor of most bacterial pathogens. The fundamental processes that determine bacterial attachment to host tissue surfaces are mediated by microbial adhesins. Host specificity and tissue tropism are characteristics exhibited by different bacteria and are determined (at least in part) by ...
Klemm, Per, Schembri, Mark A.
openaire   +2 more sources

Structural biology of gram‐positive bacterial adhesins [PDF]

Protein Science, 2011
AbstractThe structural biology of Gram‐positive cell surface adhesins is an emerging field of research, whereas Gram‐negative pilus assembly and anchoring have been extensively investigated and are well understood. Gram‐positive surface proteins known as MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and individual ...
Krishnan, Vengadesan, Sthanam V L, Narayana   +1 more
openaire   +2 more sources

Study of adhesin from Aggregatibacter actinomycetemcomitans local isolate on alveolar bone destruction in aggressive periodontitis disease

Journal of Biological Researches, 2016
Aggregatibacter actimycetemcomitans produces several virulence factors involved in the colonization of the oral cavity, destruction and inhibition of regeneration of the periodontal tissues and evasion of host defense mechanisms.
Rini Devijanti Ridwan, Tuti Kusumaningsih, Sidarningsih , Soetjipto   +3 more
doaj   +1 more source

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]

, 2012
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M, Bann JG, Barnhart MM, Dodson KW, Dodson KW, Doublie S, Gong M, Griebling TL, Henderson NS, Hess B, Holmgren A, Hooton TM, Hultgren SJ, Hung DL, Hung DL, Hung DL, Jacob-Dubuisson F, Jones CH, Justice SS, Kabsch W, Knight SD, Kuehn MJ, Kuehn MJ, Leslie A, Martinez JJ, Munera D, Nishiyama M, Painter J, Pellecchia M, Phan G, Remaut H, Remaut H, Roberts JA, Roberts JA, Rose RJ, Sauer FG, Sauer FG, Sauer FG, Saulino ET, Saulino ET, Sheldrick GM, Slonim LN, Striker R, Stromberg N, Verger D, Verger D, Volkan E, Wright KJ, Zavialov AV   +48 more
core   +2 more sources