Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry [PDF]
, 2008 P pili are multisubunit fibers essential for the attachment of uropathogenic Escherichia coli to the kidney. These fibers are formed by the noncovalent assembly of six different homologous subunit types in an array that is strictly defined in terms of ...
A. E. Ashcroft +28 more
core +2 more sources
Capsule Shields the Function of Short Bacterial Adhesins [PDF]
Journal of Bacteriology, 2004 ABSTRACT Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding.
Schembri, Mark A. +2 more
openaire +3 more sources
Molecular Plant-Microbe Interactions, 2009 Xanthomonas oryzae pv. oryzae is the causal agent of bacterial blight of rice. We have used enhanced green fluorescent protein-tagged X. oryzae pv. oryzae cells in conjunction with confocal microscopy to monitor the role of several adhesin-like functions
Amit Das +2 more
doaj +1 more source
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions [PDF]
, 2017 Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low ...
Dodson, Karen W +11 more
core +3 more sources
Evolution of host-microbe cell adherence by receptor domain shuffling
eLife, 2022 Stable adherence to epithelial surfaces is required for colonization by diverse host-associated microbes. Successful attachment of pathogenic microbes to host cells via adhesin molecules is also the first step in many devastating infections.
EmilyClare P Baker +6 more
doaj +1 more source
Forward Genetic Dissection of Biofilm Development by Fusobacterium nucleatum: Novel Functions of Cell Division Proteins FtsX and EnvC. [PDF]
, 2018 Fusobacterium nucleatum is a key member of the human oral biofilm. It is also implicated in preterm birth and colorectal cancer. To facilitate basic studies of fusobacterial virulence, we describe here a versatile transposon mutagenesis procedure and a ...
Abu Amar Mohamed Al Mamun +10 more
core +2 more sources
Helicobacter pylori Chronic Infection Selects for Effective Colonizers of Metaplastic Glands
mBio, 2023 Chronic gastric infection with Helicobacter pylori can lead to progressive tissue changes that culminate in cancer, but how H. pylori adapts to the changing tissue environment during disease development is not fully understood.
V. P. O’Brien +6 more
doaj +1 more source
Cable pili and the associated 22 kDa adhesin contribute to Burkholderia cenocepacia persistence in vivo. [PDF]
PLoS ONE, 2011 Infection by Burkholderia cenocepacia in cystic fibrosis (CF) patients is associated with poor clinical prognosis. Previously, we demonstrated that one of the highly transmissible strains, BC7, expresses cable pili and the associated 22 kDa adhesin, both
Joanna B Goldberg +4 more
doaj +1 more source
mBio, 2021 Pathogen attachment to host tissue is critical in the progress of many infections. Bacteria use adhesion in vivo to stabilize colonization and subsequently regulate the deployment of contact-dependent virulence traits.
Xavier Pierrat +3 more
doaj +1 more source
Escherichia coli K1 RS218 Interacts with Human Brain Microvascular Endothelial Cells via Type 1 Fimbria Bacteria in the Fimbriated State [PDF]
, 2005 Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E.
Cai, M. +7 more
core +2 more sources