Transcriptome changes and cAMP oscillations in an archaeal cell cycle
, 2007 Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells.
Jörg Soppa +8 more
core +1 more source
A cell cycle and nutritional checkpoint controlling bacterial surface adhesion. [PDF]
PLoS Genetics, 2014 In natural environments, bacteria often adhere to surfaces where they form complex multicellular communities. Surface adherence is determined by the biochemical composition of the cell envelope.
Aretha Fiebig +5 more
doaj +1 more source
Mechanistic insights into SteAB regulation of cell wall hydrolase RipA in Mycobacterium tuberculosis
mBioD,L-endopeptidase RipA is the major peptidoglycan (PG) hydrolase required for cell separation in Mycobacterium tuberculosis (Mtb), as RipA defects severely hinder cell division and increase antibiotic vulnerability.
Giacomo Carloni +10 more
doaj +1 more source
Spatial complexity and control of a bacterial cell cycle [PDF]
Current Opinion in Biotechnology, 2007 A major breakthrough in understanding the bacterial cell cycle is the discovery that bacteria exhibit a high degree of intracellular organization. Chromosomal loci and many protein complexes are positioned at particular subcellular sites. In this review, we examine recently discovered control mechanisms that make use of dynamically localized protein ...
Justine, Collier, Lucy, Shapiro
openaire +2 more sources
Analysis of the c-di-GMP mediated cell fate determination in Caulobacter crescentus [PDF]
, 2009 Cyclic-di-GMP (c-di-GMP) is a ubiquitous second messenger in bacteria, which has been recognized as a key regulator, antagonistically controlling the transition between motile, planktonic cells and surface attached, multicellular communities.
Abel, Sören
core +1 more source
Codon Usage Domains over Bacterial Chromosomes [PDF]
, 2006 The geography of codon bias distributions over prokaryotic genomes and its impact upon chromosomal organization are analyzed. To this aim, we introduce a clustering method based on information theory, specifically designed to cluster genes according to ...
Danchin, Antoine +11 more
core +1 more source
The global regulatory architecture of transcription during the Caulobacter cell cycle. [PDF]
PLoS Genetics, 2015 Each Caulobacter cell cycle involves differentiation and an asymmetric cell division driven by a cyclical regulatory circuit comprised of four transcription factors (TFs) and a DNA methyltransferase.
Bo Zhou +9 more
doaj +1 more source
Dynamic distribution of SeqA protein across the chromosome of Escherichia coli K-12 [PDF]
, 2010 The bacterial SeqA protein binds to hemi-methylated GATC sequences that arise in newly synthesized DNA upon passage of the replication machinery. In Escherichia coli K-12, the single replication origin oriC is a well-characterized target for SeqA, which ...
Stephen J. W. Busby +17 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]
, 2012 Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J. +7 more
core +1 more source