Results 31 to 40 of about 76,042 (156)
Role of Pili in Bacterial Conjugation [PDF]
Journal of Bacteriology, 1970 We describe techniques for isolating individual pairs of mating Escherichia coli and observing them under the light microscope. Some pairs achieved close cell-to-cell contact, whereas others remained loosely connected by invisible connections which may be F pili.
J T, Ou, T F, Anderson
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Algal exudates promote conjugation in marine Roseobacters
mBioHorizontal gene transfer (HGT) is a pivotal mechanism driving bacterial evolution, conferring adaptability within dynamic marine ecosystems. Among HGT mechanisms, conjugation mediated by type IV secretion systems (T4SSs) plays a central role in the ...
Yemima Duchin Rapp +5 more
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Type IV Coupling Proteins as Potential Targets to Control the Dissemination of Antibiotic Resistance
Frontiers in Molecular Biosciences, 2020 The increase of infections caused by multidrug-resistant bacteria, together with the loss of effectiveness of currently available antibiotics, represents one of the most serious threats to public health worldwide. The loss of human lives and the economic
Itxaso Álvarez-Rodríguez +6 more
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Exploiting Bacterial Iron Acquisition: Siderophore Conjugates [PDF]
Future Medicinal Chemistry, 2012 Siderophores are chelators synthesized by bacteria and fungi to sequester iron, which is essential for virulence and pathogenicity. Since the process involves active transport, which is highly regulated, remarkably efficient and often microbially selective, it has been exploited as a Trojan Horse method for development of microbe-selective antibiotics.
Cheng, Ji +2 more
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mBio, 2022 The emergence of the plasmid-borne colistin resistance gene mcr-1 threatens public health. IncX4-type plasmids are one of the most epidemiologically successful vehicles for spreading mcr-1 worldwide.
Lingxian Yi +6 more
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High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing
Molecular Systems Biology, 2021 Antibiotic resistance threatens our ability to treat infectious diseases, spurring interest in alternative antimicrobial technologies. The use of bacterial conjugation to deliver CRISPR‐cas systems programmed to precisely eliminate antibiotic‐resistant ...
Kevin Neil +6 more
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The evolution of infectious transmission promotes the persistence of mcr-1 plasmids
mBio, 2023 Conjugative plasmids play a vital role in bacterial evolution and promote the spread of antibiotic resistance. They usually cause fitness costs that diminish the growth rates of the host bacteria.
Jun Yang +12 more
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Bacterial polysaccharide–protein conjugate vaccines [PDF]
British Medical Bulletin, 2004 Following demonstration that chemical conjugation of polysaccharide antigens to proteins could enhance their immunogenicity in the 1920s, interest in this approach to primary prevention of bacterial infections waned with the development and widespread use of antibiotics. Emergence of resistant bacteria rekindled interest in the late 20th century, which
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BMC Genomics, 2009 Background How does the recipient cell contribute to bacterial conjugation? To answer this question we systematically analyzed the individual contribution of each Escherichia coli gene in matings using plasmid R388 as a conjugative plasmid.
de la Cruz Fernando +1 more
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Regulation of R1 Plasmid Transfer by H-NS, ArcA, TraJ, and DNA Sequence Elements
Frontiers in Microbiology, 2020 In conjugative elements such as integrating conjugative elements (ICEs) or conjugative plasmids (CPs) transcription of DNA transfer genes is a prerequisite for cells to become transfer competent, i.e., capable of delivering plasmid DNA via bacterial ...
Karin Bischof +6 more
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