Results 31 to 40 of about 955,939 (254)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Identification and characterization of small RNAs expressed by Leptospira borgpetersenii serovar Hardjo and their conservation in the genus Leptospira

BMC Microbiology
Background Leptospirosis is a global zoonotic disease affecting humans, companion animals, and domestic livestock. Clinical presentation of disease is dependent on complex interactions between host species and pathogenic species, serovars, and strains of
Ellie J Putz, Luis GV Fernandes, Darrell O Bayles, Bienvenido W Tibbs-Cortes, Bruna Petry, Sathesh K Sivasankaran, Jarlath E Nally   +6 more
doaj   +1 more source

Molecular and phenotypic characterization of Streptococcus uberis isolates from bovine mastitis milk in South Korea

Microbiology Spectrum
Streptococcus uberis, a major environmental pathogen, is frequently linked to recurrent or persistent intramammary infections, posing a challenge to mastitis control in dairy cattle. In this study, we characterized 112 S.
Hye Jeong Kang, Ju-Yeon You, Seung Hoe Kim, Yun Sang Cho, Hyun-Mi Kang   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs

EMBO Reports
Bacteria have evolved numerous biochemical processes that underpin their biology and pathogenesis. The small, non-enzymatic bacterial (Salmonella) effector SteE mediates kinase reprogramming, whereby the canonical serine/threonine host kinase GSK3 gains ...
Ioanna Panagi, Janina H Muench, Alexi Ronneau, Ines Diaz-del-Olmo, Agnel Aliyath, Xiu-Jun Yu, Hazel Mak, Enkai Jin, Jingkun Zeng, Diego Esposito, Elliott Jennings, Timesh D Pillay, Regina A Günster, Sarah L Maslen, Katrin Rittinger, Teresa L M Thurston   +15 more
doaj   +1 more source

Molecular characterization and drug resistance analysis based on whole-genome sequencing of Listeria monocytogenes isolated from food and patients in Liaocheng City from 2019 to 2022

Zhongguo shipin weisheng zazhi
ObjectiveThe genomic characteristics， toxicity， drug resistance and genetic diversity of Listeria monocytogenes （Lm） isolated from food and patients based on whole genome sequencing （WGS） in Liaocheng City from 2019 to 2022 were investigated.MethodsThe ...
QIAN Lu, ZHANG Ran, LIANG Shengnan, CUI Fangyuan, CHENG Lihong, ZHANG Xiangyuan   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Antimicrobial Susceptibility Survey of Invasive Haemophilus influenzae in the United States in 2016

Microbiology Spectrum, 2022
Antibiotics are important for the treatment and prevention of invasive Haemophilus influenzae disease. Reduced susceptibility to clinically relevant drugs, except ampicillin, has been uncommon in the United States.
Caelin C. Potts, Lorraine D. Rodriguez-Rivera, Adam C. Retchless, Sean A. Buono, Alexander T. Chen, Henju Marjuki, Amy E. Blain, Xin Wang   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source