Results 41 to 50 of about 1,050,726 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease? [PDF]

, 2013
The epoxygenase CYP2J2 has an emerging role in inflammation and vascular biology. The role of CYP2J2 in phagocytosis is not known and its regulation in human inflammatory diseases is poorly understood. Here we investigated the role of CYP2J2 in bacterial
Bishop-Bailey, D, Jonas Bystrom (200256), David Bishop-Bailey, Bystrom, J, Andrew M. Smith, Thomson, Scott J., Andrew M. Smith (251118), Thomson, SJ, Johansson, Jörgen, Gilroy, Derek W., Matthew L. Edin, David Bishop-Bailey (200332), Zeldin, DC, Edin, ML, Zeldin, D C, Andrew M Smith, Derek W. Gilroy (200322), Darryl C Zeldin, Byström, Jonas, Smith, A M, Gilroy, DW, Derek W Gilroy, Jörgen Johansson (458315), Johansson, Jörgen,, Johansson, J, Edin, M L, Scott J. Thomson, Smith, Andrew M., Matthew L Edin, Derek W. Gilroy, Gilroy, D W, Zeldin, Darryl C., Scott J Thomson, Scott J. Thomson (458314), Thomson, S J, Jonas Bystrom, Darryl C. Zeldin (16449), Darryl C. Zeldin, Bishop-Bailey, David, Edin, Matthew L., Jörgen Johansson, Matthew L. Edin (200313), Smith, AM   +42 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

One-pot, uracil-DNA-glycosylase-aided, and multi-indicator nanobiosensor detection platform for identifying Brucella melitensis from the Brucella spp

BMC Microbiology
Background Brucellosis, a zoonotic chronic contagious disease caused by Brucella spp., is primarily associated with species such as Brucella melitensis (B. melitensis) and B. abortus, among which B.
Xinggui Yang, Yue Wang, Sha Mao, Ying Liu, Fengming Chen, Junfei Huang, Xiaoyan Zeng, Hai Jiang, Shijun Li   +8 more
doaj   +1 more source

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira

mBio
Leptospirosis, caused by pathogenic bacteria from the genus Leptospira, is a global zoonosis responsible for more than one million human cases and 60,000 deaths annually. The disease also affects many domestic animal species.
Luis Guilherme Virgilio Fernandes, Camila Hamond, Bienvenido W. Tibbs-Cortes, Ellie J. Putz, Steven C. Olsen, Mitchell V. Palmer, Jarlath E. Nally   +6 more
doaj   +1 more source

Prevalence of Bacterial Species in Skin, Urine, Diarrheal Stool, and Respiratory Samples in Cats

Pathogens, 2022
Bacterial infections are a significant cause of illness and death in different animals. However, these bacterial infections could be a source of human disease or illness if these pathogenic bacteria are present in companion animals.
Dong Chan Moon, Ji-Hyun Choi, Naila Boby, Su-Jeong Kim, Hyun-Ju Song, Ho-Sung Park, Min-Chan Gil, Soon-Seek Yoon, Suk-Kyung Lim   +8 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Pentaplex real‐time PCR for differential detection of Yersinia pestis and Y. pseudotuberculosis and application for testing fleas collected during plague epizootics

MicrobiologyOpen, 2020
Upon acquiring two unique plasmids (pMT1 and pPCP1) and genome rearrangement during the evolution from Yersinia pseudotuberculosis, the plague causative agent Y. pestis is closely related to Y.
Ying Bai, Vladimir Motin, Russell E. Enscore, Lynn Osikowicz, Maria Rosales Rizzo, Andrias Hojgaard, Michael Kosoy, Rebecca J. Eisen   +7 more
doaj   +1 more source

Antimicrobial Resistance in Escherichia coli Isolates from Healthy Food Animals in South Korea, 2010–2020

Microorganisms, 2022
Antimicrobial-resistant bacteria in food animals pose a major public health threat worldwide. In this study, we aimed to assess the antimicrobial resistance profiles and resistance trends of commensal Escherichia coli isolated from the feces of healthy ...
Hyun-Ju Song, Su-Jeong Kim, Dong Chan Moon, Abraham Fikru Mechesso, Ji-Hyun Choi, Hee Young Kang, Naila Boby, Soon-Seek Yoon, Suk-Kyung Lim   +8 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source