Results 91 to 100 of about 854,281 (316)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pathological replication in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism.
Lloyd, RG, Robert G. Lloyd, Lynda Harris, Harris, L, Christian J. Rudolph, Amy L. Upton, Rudolph, CJ, Upton, AL   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops [PDF]

, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Petit M-A, El Karoui, Meriem, El Karoui, M, Bourgait, Isabelle, Gendrault-Jacquemard, A, Sourivong, Frédéric, Gendrault, Annie, Gendrault-Jacquemard, Gendrault-Jacquemard A, Chiapello H, Chiapello, H, Sourivong F, Bourgait I, Heuclin G, El Karoui M, El Karoui, Meriem, M., Heuclin, G, Petit, M-A, Bourgait, I, Heuclin, Gaëlle, Chiapello, Helene, Petit, Marie Agnès, Petit, Marie Agnes, M. A., Sourivong, F, Gendrault, Annie   +23 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Orf protein modulates phage and bacterial pathways of genetic recombination [PDF]

, 2008
The emergence of novel pathogenic organisms due to the acquisition of virulencedeterminants from bacteriophages has generated significant interest in the pathways responsible for genomic rearrangements.
Bowers, Laura Yvonne
core  

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +1 more source

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase [PDF]

, 1991
Mammalian DNA cytosine-5-methyltransferase (MTase, EC 2.1.1.37) is an essential component for establishing and maintaining cell-type specific methylation patterns in the genome. The cDNAfor the murine enzyme was previously cloned in segments.
Häuselmann, Remo, Bestor, Timothy H., Bestor, T. H., Page, A. W., Page, Andrea W., Hergersberg, M., Leonhardt, Heinrich, Häuselmann, R., Czank, A., Czank, Andreas, Schaffner, Walter, Schaffner, W., Hergersberg, Martin, Leonhardt, H.   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Determinants of the Bacterial Diversity in Manipulated and Natural Soils [PDF]

, 2008
Soils harbor highly diverse bacterial communities. It is still poorly understood whether functional redundancy or a multitude of ecological niche modify the abundance and community composition of bacteria in soil.
Zul, Delita
core