Results 101 to 110 of about 854,281 (316)

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Fisher, LM, Dias, M, PAN X. S, Pan, XS, Palumbo, M, DIAS M, FISHER L. M., PALUMBO, MANLIO   +7 more
core   +1 more source

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. [PDF]

, 2008
BACKGROUND: Human and animal health is constantly under threat by emerging pathogens that have recently acquired genetic determinants that enhance their survival, transmissibility and virulence.
Oyston, Petra C. F., Titball, Richard W., Hinds, Jason, Richard W Titball, Wren, Brendan W, Dawson, LF, Titball Richard W, Dawson Lisa F, Lisa F Dawson, Richard A Stabler, Wren, Brendan W., Oyston, Petra CF, Titball, RW, Stabler, Richard A, Dawson, Lisa F, Dawson, Lisa F., Hinds Jason, Oyston, PCF, Stabler, Richard A., Stabler Richard A, Wren, BW, Witney, AA, Petra CF Oyston, Titball, Richard W, Oyston Petra CF, Witney, Adam A, Jim Wade, Witney Adam A, Witney, Adam A., Hinds, J, Wren Brendan W, Wade, Jim, Jason Hinds, Wade, J, Stabler, RA, Oyston, PC, Adam A Witney, Wade Jim, Brendan W Wren   +38 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus

, 2011
Objectives The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with ...
Rahman, Khondaker; id_orcid, Thurston, DE, Taylor, PW, Feuerbaum, EA, Helena Rosado, David E. Thurston, Rahman, KM, Peter W. Taylor, Rosado, H, Hinds, J, Khondaker M. Rahman, Jason Hinds, Eva-Anne Feuerbaum   +12 more
core   +1 more source

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei [PDF]

, 1992
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but
Heinz-Ulrich Weier, Page, A.W., Weier, H.U., Andrea W. Page, Bestor, Timothy H., Bestor, T. H., Heinrich Leonhardt, Page, A. W., Page, Andrea W., Leonhardt, Heinrich, Weier, H. U., Weier, Heinz-Ulrich, Bestor, T.H., Timothy H. Bestor, Leonhardt, H.   +14 more
core   +1 more source

DNA origami-enhanced binding of aptamers to Staphylococcus aureus cells

Biosensors and Bioelectronics: X
The combination of DNA origami nanostructures and aptamers provides a powerful technology for diagnostic assays. Here, we functionalized a DNA origami nanostructure with a Protein-A binding aptamer to target Staphylococcus aureus bacterial cells.
Yasaman Ahmadi, Trishant R. Umrekar, Natalie Mutter, Morgan Beeby, Ivan Barišić   +4 more
doaj   +1 more source

DnaG Primase—A Target for the Development of Novel Antibacterial Agents

Antibiotics, 2018
The bacterial primase—an essential component in the replisome—is a promising but underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different structure than the human primase.
Stefan Ilic, Shira Cohen, Meenakshi Singh, Benjamin Tam, Adi Dayan, Barak Akabayov   +5 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Folding of the transcription factor Brinker and interactions of the bacterial second messenger c-di-GMP studied by NMR [PDF]

, 2013
Nuclear magnetic resonance (NMR) spectroscopy is a technique, which allows the non-invasive investigation of structures, dynamics and interactions of biomolecules.
Gentner, Martin
core   +1 more source

DNA Wrapping by a tetrameric bacterial histone

Nature Communications
Abstract Histones are conserved DNA-packaging proteins found across all domains of life. In eukaryotes, canonical histones form octamers that wrap ~147 base pairs (bp) of DNA into nucleosomes, while in archaea they form dimers that polymerize into extended hypernucleosomes.
Yimin Hu, Samuel Schwab, Kaiyu Qiu, Yunsen Zhang, Kerstin Bär, Heidi Reichle, Aurora Panzera, Andrei N. Lupas, Marcus D. Hartmann, Remus T. Dame, Vikram Alva, Birte Hernandez Alvarez   +11 more
openaire   +4 more sources