Results 21 to 30 of about 3,675,539 (309)
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
Proceedings of the National Academy of Sciences of the United States of America, 2001 The Toll-like receptor (TLR) family consists of phylogenetically conserved transmembrane proteins, which function as mediators of innate immunity for recognition of pathogen-derived ligands and subsequent cell activation via the Toll/IL-1R signal pathway.
S. Bauer +7 more
semanticscholar +1 more source
STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
Медицинская иммунология, 2014 Bacterial DNA, along with other bacterial pathogen-associated molecular structures, may activate both innate and adaptive immune systems. This activity is associated with by nonmethylated CpG dinucleotides, which are present in the bDNA molecule, and it ...
V. S. Polovinkina, E. Yu. Markov
doaj +1 more source
Gut Pathogens, 2016 BackgroundThe advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have detected the presence of contaminating microbial DNA within reagents.
Angela Glassing +4 more
semanticscholar +1 more source
Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. [PDF]
PLoS Computational Biology, 2013 There are 10× more bacterial cells in our bodies from the microbiome than human cells. Viral DNA is known to integrate in the human genome, but the integration of bacterial DNA has not been described. Using publicly available sequence data from the human
David R Riley +6 more
doaj +1 more source
Bacterial Extracellular DNA Promotes β-Amyloid Aggregation
Microorganisms, 2021 Alzheimer’s disease is associated with prion-like aggregation of the amyloid β (Aβ) peptide and the subsequent accumulation of misfolded neurotoxic aggregates in the brain.
George Tetz, Victor Tetz
doaj +1 more source
Organization of the bacterial nucleoid by DNA-bridging proteins and globular crowders [PDF]
Frontiers in Microbiology, 2023, 14, 2023 The genomic DNA of bacteria occupies only a fraction of the cell called the nucleoid, although it is not bounded by any membrane and would occupy a volume hundreds of times larger than the cell in the absence of constraints. The two most important contributions to the compaction of the DNA coil are the cross-linking of the DNA by nucleoid proteins ...
arxiv +1 more source
European Journal of Clinical Microbiology and Infectious Diseases, 2016 Blood is considered to be a sterile microenvironment, in which bacteria appear only periodically. Previously used methods allowed only for the detection of either viable bacteria with low sensitivity or selected species of bacteria.
T. Gosiewski +9 more
semanticscholar +1 more source
Bacterial DNA Extraction Using Individual Enzymes and Phenol/Chloroform Separation†
Journal of Microbiology & Biology Education, 2017 Marmur (4) developed one of the first detailed comprehensive methods for purifying bacterial DNA. This procedure is now outdated, and can be difficult to follow for those with limited experience in molecular biology.
M. H. Wright, Joseph Adelskov, A. Greene
semanticscholar +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, 2005 Three group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence ...
Raymond SW Tsang +5 more
doaj +1 more source
Frontiers in Genetics, 2020 Bacterial infections of root canals and the surrounding dental hard tissue are still a challenge due to biofilm formation as well as the complex root canal anatomy.
Torsten Sterzenbach +4 more
doaj +1 more source