Results 211 to 220 of about 1,488,259 (274)

Bacterial extracellular vesicles from Streptococcus mutans drive OSCC progression through β-catenin signaling. [PDF]

Sci Rep
Cao G, Jiang Y, Li X, Liu R, Liu K, Balcha F, Ding M, Yuan M, Li T, Fang Y.   +9 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

A One Health perspective on bacterial extracellular vesicles as mediators of antimicrobial resistance spread. [PDF]

ISME Commun
Huang H, Ghosh D, Worrich A.
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Interkingdom signaling elicited by bacterial extracellular vesicles in human cystic fibrosis airway epithelium and neutrophils. [PDF]

Front Cell Infect Microbiol
Lakkappa N, Luthra D, Kumar P, Almenar Perez E, Hynes J, McNally P, Ringholz F, El Nazir B, Bateman G, Rodgers AM, Brew K, Takayama S, Taggart CC, Tirouvanziam R, Coppinger JA.   +14 more
europepmc   +1 more source

Applications of nanocarrier‐delivered RNA interference in agricultural biological control (2009–2025)

New Plant Protection, EarlyView.
Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang, Woo‐Jong Hong, Xu Jiang, Ki‐hong Jung, Yuan Hu Xuan   +4 more
wiley   +1 more source

Bacterial extracellular vesicles as emerging platforms to combat multidrug-resistant bacterial infections: Mechanisms, therapeutic applications, and future prospects. [PDF]

Virulence
Zhou Z, Shi Y, Fu Y, Huang Y, Song Y, Li C.   +5 more
europepmc   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Optimizing genetic engineering approaches for protein loading into bacterial extracellular vesicles for vaginal drug delivery. [PDF]

J Control Release
Steinman D, Hemanth Kumar VS, McIlvaine RA, Tyagi P, Kang H, Alam R, Liu A, Jewell CM, Plotkin A, Burd I, Molinari S, Zierden HC.   +11 more
europepmc   +1 more source

Identification of Novel CD52+ Fibroblasts in Nodular Prostatic Hyperplasia

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms are strongly associated with chronic prostate inflammation and stromal remodeling, yet the stromal cell programs that emerge during inflammatory, nodular remodeling remain incompletely defined. A Toxoplasma gondii infection model produces persistent inflammation and
Oliver R. Strobel, Hanyu Xia, James P. Ropa, Douglas W. Strand, Travis J. Jerde, Gustavo Arrizabalaga   +5 more
wiley   +1 more source