Results 41 to 50 of about 861,479 (259)

Sodium butyrate augments the antibacterial activity of tetracycline against clinical isolates of multidrug-resistant Vibrio cholerae

Gut Pathogens
Background Antibiotic resistance poses a major challenge in treating Vibrio cholerae infections. One promising method to counter resistance is the co-administration of antibiotics with non-antibiotic adjuvants to enhance their efficacy.
Sushmita Kundu, Sourin Alu, Abhishek Singh, Animesh Gope, Ranjan Kumar Nandy, Asish K. Mukhopadhyay, Shin-ichi Miyoshi, Nabendu Sekhar Chatterjee, Sushmita Bhattacharya   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The History of Bovine Genital Campylobacteriosis in the Face of Political Turmoil and Structural Change in Cattle Farming in Germany

Veterinary Sciences, 2023
Contagious bovine genital campylobacteriosis (BGC), also known as bovine venereal campylobacteriosis, is a disease relevant to international trade listed by the World Organization for Animal Health (WOAH).
Hosny El-Adawy, Helmut Hotzel, Herbert Tomaso, Heinrich Neubauer   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Exploring the burden of diarrheal disease and associated WASH practices in rural West Bengal, India: an explanatory sequential mixed-method approach

Scientific Reports
Diarrheal diseases continue to be a major public health concern in low- and middle-income countries, where insufficient water, sanitation, and hygiene (WASH) practices lead to a substantial community burden.
Suman Kanungo, Shubhajit Pahari, Aritra Paul, Rounik Talukdar, Sombuddha Biswas, Sougata Chatterjee, Diplina Barman, Debjit Chakraborty, Pramit Ghosh, Bipul Chandra Karmakar, Atreyi Chakrabarti, Swati Pramanick, Asish Kumar Mukhopadhyay, Ranjan Kumar Nandy, Alok Kumar Deb, Falguni Debnath, Shanta Dutta, Debasis Roy, Mukti Sadhan Maiti, Dipankar Maji   +19 more
doaj   +1 more source

Product review on the IMD serogroup B vaccine Bexsero®

Human Vaccines & Immunotherapeutics, 2022
Bexsero® is a multicomponent vaccine composed of four major proteins of Neisseria meningitidis: the fHbp, NHBA, NadA and PorA. This vaccine was licensed against invasive meningococcal disease (IMD) due to serogroup B isolates.
Ala-Eddine Deghmane, Muhamed-Kheir Taha
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparative metagenomic analysis of diarrheal and non-diarrheal gut microbiome delineating the identification of prospective prognostic markers and probiotics to protect from diarrhea: a brief report

Frontiers in Cellular and Infection Microbiology
IntroductionDiarrhea is a leading contributor of mortality globally. To mitigate its disease burden, improved prognosis and alternative therapeutic approaches must be deployed. A cross-sectional gut microbiome analysis of 23 non-diarrheal and 5 diarrheal
Rituparna De, Suman Kanungo, Asish K. Mukhopadhyay, Shanta Dutta   +3 more
doaj   +1 more source