Results 41 to 50 of about 971,285 (315)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Estrogen and bacterial infection

Frontiers in Immunology
Gender differences exist in the susceptibility, incidence, progression, and prognosis of bacterial infections in males and females, influenced by various factors including lifestyle and habits. Multiple reports have indicated that estrogen plays a crucial immunomodulatory role in many pathogenic microbial infections, highlighting a complex relationship
Longyan Hong, Longyan Hong, Hao Liang, Wenqing Man, Yinghui Zhao, Pengbo Guo, Pengbo Guo   +6 more
openaire   +3 more sources

Lactose fermenting enteroinvasive Escherichia coli from diarrhoeal cases confers enhanced virulence

Scientific Reports
Enteroinvasive Escherichia coli (EIEC), known for causing bacillary dysentery akin to Shigella species, comprises both lactose-fermenting (LF) and non-lactose-fermenting (NLF) isolates.
Debjani Ghosh, Prolay Halder, Prosenjit Samanta, Goutam Chowdhury, Sreeja Shaw, Puja Bose, Deboleena Roy, Nivedita Roy, Kei Kitahara, Thandavarayan Ramamurthy, Hemanta Koley, Shin-ichi Miyoshi, Shanta Dutta, Asish Kumar Mukhopadhyay   +13 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The missing thread of One Health efforts: improper drug disposal as an overlooked driver of antimicrobial resistance

mSphere
With gradual recognition of the components and the stakeholders, “One Health approach” became a global strategy for mitigating antimicrobial resistance (AMR).
Sandip Mukhopadhyay, Falguni Debnath, Debjit Chakraborty   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring the burden of diarrheal disease and associated WASH practices in rural West Bengal, India: an explanatory sequential mixed-method approach

Scientific Reports
Diarrheal diseases continue to be a major public health concern in low- and middle-income countries, where insufficient water, sanitation, and hygiene (WASH) practices lead to a substantial community burden.
Suman Kanungo, Shubhajit Pahari, Aritra Paul, Rounik Talukdar, Sombuddha Biswas, Sougata Chatterjee, Diplina Barman, Debjit Chakraborty, Pramit Ghosh, Bipul Chandra Karmakar, Atreyi Chakrabarti, Swati Pramanick, Asish Kumar Mukhopadhyay, Ranjan Kumar Nandy, Alok Kumar Deb, Falguni Debnath, Shanta Dutta, Debasis Roy, Mukti Sadhan Maiti, Dipankar Maji   +19 more
doaj   +1 more source

WGS based analysis of acquired antimicrobial resistance in human and non-human Acinetobacter baumannii isolates from a German perspective

BMC Microbiology, 2021
Background Acinetobacter baumannii ability to develop and acquire resistance makes it one of the most critical nosocomial pathogens globally. Whole-genome sequencing (WGS) was applied to identify the acquired or mutational variants of antimicrobial ...
Gamal Wareth, Christian Brandt, Lisa D. Sprague, Heinrich Neubauer, Mathias W. Pletz   +4 more
doaj   +1 more source

The History of Bovine Genital Campylobacteriosis in the Face of Political Turmoil and Structural Change in Cattle Farming in Germany

Veterinary Sciences, 2023
Contagious bovine genital campylobacteriosis (BGC), also known as bovine venereal campylobacteriosis, is a disease relevant to international trade listed by the World Organization for Animal Health (WOAH).
Hosny El-Adawy, Helmut Hotzel, Herbert Tomaso, Heinrich Neubauer   +3 more
doaj   +1 more source