Results 31 to 40 of about 2,574,090 (268)

Lactose fermenting enteroinvasive Escherichia coli from diarrhoeal cases confers enhanced virulence

Scientific Reports
Enteroinvasive Escherichia coli (EIEC), known for causing bacillary dysentery akin to Shigella species, comprises both lactose-fermenting (LF) and non-lactose-fermenting (NLF) isolates.
Debjani Ghosh, Prolay Halder, Prosenjit Samanta, Goutam Chowdhury, Sreeja Shaw, Puja Bose, Deboleena Roy, Nivedita Roy, Kei Kitahara, Thandavarayan Ramamurthy, Hemanta Koley, Shin-ichi Miyoshi, Shanta Dutta, Asish Kumar Mukhopadhyay   +13 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel SNP-based multiplex PCR profiling divulges contemporary genetic patterns in Haitian variant Vibrio cholerae O1 clinical isolates

Microbiology Spectrum
The massive cholera outbreak in Haiti in 2010 has drawn the attention of both medical professionals and public health officials worldwide. The hypervirulent Vibrio cholerae O1 El Tor strains responsible for this outbreak were not only confined to Haiti ...
Prosenjit Samanta, Priyanka Ghosh, Goutam Chowdhury, Sreeja Shaw, Arindam Naha, Deboleena Roy, Ayumu Ohno, Shin-ichi Miyoshi, Thandavarayan Ramamurthy, Asish Kumar Mukhopadhyay   +9 more
doaj   +1 more source

First record of the human infection of Brucella melitensis in Kyrgyzstan: evidence from whole-genome sequencing-based analysis

Infectious Diseases of Poverty, 2022
Background Brucellosis, a zoonosis mainly transmitted by consumption of unpasteurized dairy products as well as direct contact with infected animals, is endemic in Kyrgyzstan.
Kalysbek Kydyshov, Nurbolot Usenbaev, Stalbek Berdiev, Aigul Dzhaparova, Aziza Abidova, Nuraiym Kebekbaeva, Murat Abdyraev, Gamal Wareth, Hanka Brangsch, Falk Melzer, Heinrich Neubauer, Mathias W. Pletz   +11 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The missing thread of One Health efforts: improper drug disposal as an overlooked driver of antimicrobial resistance

mSphere
With gradual recognition of the components and the stakeholders, “One Health approach” became a global strategy for mitigating antimicrobial resistance (AMR).
Sandip Mukhopadhyay, Falguni Debnath, Debjit Chakraborty   +2 more
doaj   +1 more source

Epidemiological Analysis on the Occurrence of Salmonella enterica Subspecies enterica Serovar Dublin in the German Federal State Schleswig-Holstein Using Whole-Genome Sequencing

Microorganisms, 2023
The cattle-adapted serovar Salmonella Dublin (S. Dublin) causes enteritis and systemic diseases in animals. In the German federal state Schleswig-Holstein, S. Dublin is the most important serovar in cattle indicating an endemic character of the infection.
Silvia García-Soto, Jörg Linde, Ulrich Methner   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Exploring the burden of diarrheal disease and associated WASH practices in rural West Bengal, India: an explanatory sequential mixed-method approach

Scientific Reports
Diarrheal diseases continue to be a major public health concern in low- and middle-income countries, where insufficient water, sanitation, and hygiene (WASH) practices lead to a substantial community burden.
Suman Kanungo, Shubhajit Pahari, Aritra Paul, Rounik Talukdar, Sombuddha Biswas, Sougata Chatterjee, Diplina Barman, Debjit Chakraborty, Pramit Ghosh, Bipul Chandra Karmakar, Atreyi Chakrabarti, Swati Pramanick, Asish Kumar Mukhopadhyay, Ranjan Kumar Nandy, Alok Kumar Deb, Falguni Debnath, Shanta Dutta, Debasis Roy, Mukti Sadhan Maiti, Dipankar Maji   +19 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source