Results 31 to 40 of about 2,424,208 (316)

Bistability and Bacterial Infections

PLoS ONE, 2010
Bacterial infections occur when the natural host defenses are overwhelmed by invading bacteria. The main component of the host defense is impaired when neutrophil count or function is too low, putting the host at great risk of developing an acute infection.
Roy Malka, Eliezer Shochat, Vered Rom-Kedar   +2 more
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Utilizing the effectiveness of phage cocktail to combat Shigella and Salmonella infections and their polymicrobial biofilm control activity

BMC Microbiology
Background Shigella and Salmonella are major foodborne and waterborne pathogens responsible for acute gastrointestinal infections and significant global morbidity and mortality.
Payel Mondal, Bani Mallick, Tapas Haldar, Anaswara Ramesh, Arpita Sarbajna, Hemanta Koley, Santasabuj Das   +6 more
doaj   +1 more source

First record of the human infection of Brucella melitensis in Kyrgyzstan: evidence from whole-genome sequencing-based analysis

Infectious Diseases of Poverty, 2022
Background Brucellosis, a zoonosis mainly transmitted by consumption of unpasteurized dairy products as well as direct contact with infected animals, is endemic in Kyrgyzstan.
Kalysbek Kydyshov, Nurbolot Usenbaev, Stalbek Berdiev, Aigul Dzhaparova, Aziza Abidova, Nuraiym Kebekbaeva, Murat Abdyraev, Gamal Wareth, Hanka Brangsch, Falk Melzer, Heinrich Neubauer, Mathias W. Pletz   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sodium butyrate augments the antibacterial activity of tetracycline against clinical isolates of multidrug-resistant Vibrio cholerae

Gut Pathogens
Background Antibiotic resistance poses a major challenge in treating Vibrio cholerae infections. One promising method to counter resistance is the co-administration of antibiotics with non-antibiotic adjuvants to enhance their efficacy.
Sushmita Kundu, Sourin Alu, Abhishek Singh, Animesh Gope, Ranjan Kumar Nandy, Asish K. Mukhopadhyay, Shin-ichi Miyoshi, Nabendu Sekhar Chatterjee, Sushmita Bhattacharya   +8 more
doaj   +1 more source

Systematic review of brucellosis in Kenya: disease frequency in humans and animals and risk factors for human infection

BMC Public Health, 2016
Background Brucellosis is a debilitating zoonotic disease affecting humans and animals. A comprehensive, evidence-based assessment of literature and officially available data on animal and human brucellosis for Kenya are missing.
J. Njeru, G. Wareth, F. Melzer, K. Henning, M. W. Pletz, R. Heller, H. Neubauer   +6 more
doaj   +1 more source

Epidemiological Analysis on the Occurrence of Salmonella enterica Subspecies enterica Serovar Dublin in the German Federal State Schleswig-Holstein Using Whole-Genome Sequencing

Microorganisms, 2023
The cattle-adapted serovar Salmonella Dublin (S. Dublin) causes enteritis and systemic diseases in animals. In the German federal state Schleswig-Holstein, S. Dublin is the most important serovar in cattle indicating an endemic character of the infection.
Silvia García-Soto, Jörg Linde, Ulrich Methner   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Lactose fermenting enteroinvasive Escherichia coli from diarrhoeal cases confers enhanced virulence

Scientific Reports
Enteroinvasive Escherichia coli (EIEC), known for causing bacillary dysentery akin to Shigella species, comprises both lactose-fermenting (LF) and non-lactose-fermenting (NLF) isolates.
Debjani Ghosh, Prolay Halder, Prosenjit Samanta, Goutam Chowdhury, Sreeja Shaw, Puja Bose, Deboleena Roy, Nivedita Roy, Kei Kitahara, Thandavarayan Ramamurthy, Hemanta Koley, Shin-ichi Miyoshi, Shanta Dutta, Asish Kumar Mukhopadhyay   +13 more
doaj   +1 more source