Results 41 to 50 of about 2,216,688 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Brain effects of gestating germ-free persist in mouse neonates despite acquisition of a microbiota at birth

open access: yesFrontiers in Neuroscience, 2023
At birth, mammals experience a massive colonization by microorganisms. We previously reported that newborn mice gestated and born germ-free (GF) have increased microglial labeling and alterations in developmental neuronal cell death in the hippocampus ...
Alexandra Castillo-Ruiz   +7 more
doaj   +1 more source

Human Rhinovirus at Naturally Occurring COPD Exacerbation [PDF]

open access: yes, 2015
Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the lung caused by an abnormal response to particles and noxious gases, primarily cigarette smoke.
George, SN
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cotton and Surgical Face Masks in Community Settings: Bacterial Contamination and Face Mask Hygiene

open access: yesFrontiers in Medicine, 2021
During the current COVID-19 pandemic, the use of face masks has become increasingly recommended and even mandatory in community settings. To evaluate the risk of bacterial cross-contamination, this study analyzed the bacterial bioburden of disposable ...
Lize Delanghe   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Proximate Composition, Retained Water, and Bacterial Load for Two Sizes of Hybrid Catfish (Ictalurus furcatus × Ictalurus punctatus) Fillets at Different Process Steps

open access: yesFoods, 2023
The catfish processors in the US are required to state the maximum percentage of retained water content (RWC) on the product label. The objectives of our study were to quantify the RWC of processed hybrid catfish fillets from proximate composition and ...
Manirul Haque, Juan L. Silva
doaj   +1 more source

STUDIES ON BACTERIAL LOAD OF FISH CONTAINER-II

open access: yesNIPPON SUISAN GAKKAISHI, 1963
In the previous paper1), the author reported on the invasion of the Takikawa's so-called pathogenic halophilic bacteria into the material of wooden fish container. It was also disclosed that the bacteria might easily migrate into inner part of such rough-grained wooden material as ceder or pine.
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

ABLE: An Automated Bacterial Load Estimator for the Urinoculture Screening

open access: yesProceedings of the 5th International Conference on Pattern Recognition Applications and Methods, 2016
Urinary Tract Infections (UTIs) are very common in women, babies and the elderly. The most frequent cause is a bacterium, called Escherichia Coli, which usually lives in the digestive system and in the bowel. Infections can target the urethra, bladder or kidneys.
Andreini, Paolo   +4 more
openaire   +3 more sources

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