Results 131 to 140 of about 85,925 (266)

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Biophysical investigation of bacterial aggregation [PDF]

, 2008
In nature, bacteria usually exist as aggregates, in order to withstand changes in environmental conditions. Bacterial aggregation is of great significance in the field of biotechnology, environmental studies and medicine.
Eboigbodin, Kevin Efosa
core  

Unlocking the potential of bacterial membrane vesicles: Advances in isolation techniques and biomedical applications [PDF]

Bacterial membrane vesicles (MVs) are nanosized, lipid bilayer-enclosed structures released by both Gram-positive (commonly referred as MVS, bacterial membrane vesicles) and Gram-negative bacteria (commonly referred as OMVs, outer membrane vesicles and ...
Sebastian, Victor, Arruebo, Manuel, Canalejo-Marco, Gonzalo   +2 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Bacterial outer membrane vesicles: A new mechanism for NOD1-dependent responses in epithelial cells

, 2022
Bacterial outer membrane vesicles: A new mechanism for NOD1-dependent responses in epithelial ...
J K Davies (13423464), S Girardin (13623139), H C Parkington (13524604), L Turnbull (11085330), S Firth (13531915), D Philpott (13623136), M Hutton (13591549), J Viala (13623133), C B Whitchurch (13610569), A Karrar (13623130), H A Coleman (13524607), M Kaparakis (13623121), L Carneiro (13623124), L Le Bourhis (13623127), Johnson Mak (13082904), R L Ferrero (13423611)   +15 more
core  

Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles. [PDF]

Front Microbiol, 2023
Xiao M, Li G, Yang H.
europepmc   +1 more source

Dual‐Stage Microneedle Patch With Lipid Droplet‐Mediated ‘Capture‐Kill’ and Sustained Release for Enhanced Wound Healing

Advanced Science, EarlyView.
We report a lipid‐droplet‐engineered, gallium‐loaded sonodynamic therapeutic platform (LDTG) incorporated into a bilayer microneedle (MN) patch co‐delivering all‐trans retinoic acid (ATRA), termed LDTG A‐MNs, for synergistic antibacterial therapy and accelerated wound repair.
Peng Jiang, Meijun Jiang, Jiapeng Lei, Wen Zhang, Huiyuan Yang, Xueyang Wang, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

, 2010
Gram-negative bacteria produce outer membrane vesicles (OMVs) that contain biologically active proteins and perform diverse biological processes. Unlike other secretion mechanisms, OMVs enable bacteria to secrete insoluble molecules in addition to and ...
Adam Kulp, Meta J. Kuehn
core   +1 more source

Isolation and Quantification of Bacterial Membrane Vesicles for Quantitative Metabolic Studies Using Mammalian Cell Cultures. [PDF]

Cells, 2023
Kretschmer M, Müller J, Henke P, Otto V, Rodriguez AA, Müsken M, Jahn D, Borrero-de Acuña JM, Neumann-Schaal M, Wegner A.   +9 more
europepmc   +1 more source