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Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng +9 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li +3 more
wiley +1 more source
Membrane vesicle-mediated bacterial communication
Membrane vesicle-mediated bacterial communicationopenaire
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Composition and functions of bacterial membrane vesicles
Nature Reviews Microbiology, 2023Extracellular vesicles are produced by species across all domains of life, suggesting that vesiculation represents a fundamental principle of living matter. In Gram-negative bacteria, membrane vesicles (MVs) can originate either from blebs of the outer membrane or from endolysin-triggered explosive cell lysis, which is often induced by genotoxic stress.
Toyofuku, Masanori +3 more
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Types and origins of bacterial membrane vesicles
Nature Reviews Microbiology, 2018Most bacteria release membrane vesicles (MVs) that contain specific cargo molecules and have diverse functions, including the transport of virulence factors, DNA transfer, interception of bacteriophages, antibiotics and eukaryotic host defence factors, cell detoxification and bacterial communication.
Toyofuku, Masanori +2 more
openaire +4 more sources
Immune modulation by bacterial outer membrane vesicles
Nature Reviews Immunology, 2015Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane nanostructures that contain many components found within the parent bacterium. Until recently, OMVs were dismissed as a by-product of bacterial growth; however, findings within the past ...
Maria, Kaparakis-Liaskos +1 more
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Bacterial membrane vesicles for vaccine applications
Advanced Drug Delivery Reviews, 2022Vaccines have been highly successful in the management of many diseases. However, there are still numerous illnesses, both infectious and noncommunicable, for which there are no clinically approved vaccine formulations. While there are unique difficulties that must be overcome in the case of each specific disease, there are also a number of common ...
Nishta, Krishnan +5 more
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Pathogenesis Mediated by Bacterial Membrane Vesicles
2021The release of extracellular vesicles (EVs) is a process conserved across the three domains of life. Amongst prokaryotes, EVs produced by Gram-negative bacteria, termed outer membrane vesicles (OMVs), were identified more than 50 years ago and a wealth of literature exists regarding their biogenesis, composition and functions. OMVs have been implicated
William J, Gilmore +2 more
openaire +2 more sources