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Interdisciplinary Medicine, EarlyView.This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao +7 more
wiley +1 more source
Membrane vesicle-mediated bacterial communication
Membrane vesicle-mediated bacterial communicationopenaire
The Therapeutic Benefit of Bacterial Membrane Vesicles [PDF]
International Journal of Molecular Sciences, 2017 The therapeutic potential of extracellular vesicles from eukaryotes has gained strong interest in recent years. However, research into the therapeutic application of their bacterial counterparts, known as bacterial membrane vesicles, is only just beginning to be appreciated.
Maria Kaparakis-Liaskos +2 more
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Composition and functions of bacterial membrane vesicles [PDF]
Nature Reviews Microbiology, 2023 Extracellular vesicles are produced by species across all domains of life, suggesting that vesiculation represents a fundamental principle of living matter. In Gram-negative bacteria, membrane vesicles (MVs) can originate either from blebs of the outer membrane or from endolysin-triggered explosive cell lysis, which is often induced by genotoxic stress.
Stefan Schild +2 more
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Types and origins of bacterial membrane vesicles [PDF]
Nature Reviews Microbiology, 2018 Most bacteria release membrane vesicles (MVs) that contain specific cargo molecules and have diverse functions, including the transport of virulence factors, DNA transfer, interception of bacteriophages, antibiotics and eukaryotic host defence factors, cell detoxification and bacterial communication.
Leo Eberl +2 more
exaly +5 more sources
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Bacterial membrane vesicles for vaccine applications
Advanced Drug Delivery Reviews, 2022Vaccines have been highly successful in the management of many diseases. However, there are still numerous illnesses, both infectious and noncommunicable, for which there are no clinically approved vaccine formulations. While there are unique difficulties that must be overcome in the case of each specific disease, there are also a number of common ...
Nishta, Krishnan +5 more
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Pathogenesis Mediated by Bacterial Membrane Vesicles
2021The release of extracellular vesicles (EVs) is a process conserved across the three domains of life. Amongst prokaryotes, EVs produced by Gram-negative bacteria, termed outer membrane vesicles (OMVs), were identified more than 50 years ago and a wealth of literature exists regarding their biogenesis, composition and functions. OMVs have been implicated
William J, Gilmore +2 more
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Bacterial membrane vesicles in inflammatory bowel disease
Life Sciences, 2022Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation with no cure. The intestine is fundamental in controlling human health. Disruption of the microbial ecosystem in the intestine is considered an important cause of IBD.
Qichen, Shen +4 more
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