Results 1 to 10 of about 131,361 (186)
Bacterial outer membrane vesicle-based cancer nanovaccines [PDF]
Cancer Biology & Medicine, 2022 Tumor vaccines, a type of personalized tumor immunotherapy, have developed rapidly in recent decades. These vaccines evoke tumor antigen-specific T cells to achieve immune recognition and killing of tumor cells.
Xiaoyu Gao +3 more
doaj +4 more sources
Outer Membrane Vesicle Vaccine Platforms. [PDF]
BioDrugs, 2023 Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence factor for bacteria, helping them to survive through harsh environmental conditions. Native OMVs, naturally-released from bacteria, are produced at a level too low for vaccine manufacturing, requiring ...
Micoli F, Adamo R, Nakakana U.
europepmc +3 more sources
Bacterial outer membrane vesicles and vaccine applications [PDF]
Frontiers in Immunology, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo +10 more
core +8 more sources
Bacterial outer membrane vesicle nanorobot. [PDF]
Proc Natl Acad Sci U S AAutonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease
Tang S +15 more
europepmc +4 more sources
Lipid a remodeling modulates outer membrane vesicle biogenesis by Porphyromonas gingivalis [PDF]
Journal of BacteriologyOuter membrane vesicles (OMVs) are small membrane enclosed sacs released from bacteria which serve as carriers of biomolecules that shape interactions with the surrounding environment. The periodontal pathogen, Porphyromonas gingivalis, is a prolific OMV
Sarah R. Alaei +10 more
doaj +2 more sources
Outer membrane vesicle vaccines for Neisseria gonorrhoeae. [PDF]
Nat Rev Urol, 2022 Multidrug-resistant Neisseria gonorrhoeae is a global health problem, and the development of a vaccine is considered essential for the effective control of gonorrhoea. The use of outer membrane vesicle vaccines to prevent N. gonorrhoeae infection has garnered considerable interest, and a recent study using a mouse model of experimental gonococcal ...
Semchenko EA, Seib KL.
europepmc +5 more sources
Abolishing PorB-induced mitophagy enhances gonococcal outer membrane vesicle vaccine efficacy [PDF]
Emerging Microbes and InfectionsThe emergence and global spread of ceftriaxone-resistant Neisseria gonorrhoeae underscores the urgent need for an effective vaccine. Gonococcal outer membrane vesicles (OMVs) are promising as vaccine platform, but their efficacy is potentially ...
Haoyu Ge +6 more
doaj +2 more sources
Emerging role of bacterial outer membrane vesicle in gastrointestinal tract [PDF]
Gut Pathogens, 2023 Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles that encapsulate nucleic acids, proteins, lipids, and other ...
Cheng-mei Tian +8 more
doaj +2 more sources
LDH as an adjuvant makes Brucella outer-membrane vesicles and outer-membrane vesicle-associated proteins highly protective in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Existing Brucella vaccines are attenuated and can cause vaccine-associated brucellosis; and these safety concerns have affected their application.
Xiaoyu Deng +8 more
doaj +2 more sources
Outer membrane vesicles: A bacterial-derived vaccination system
Frontiers in Microbiology, 2022 Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and ...
Linda A. Lieberman
doaj +3 more sources