Results 11 to 20 of about 84,904 (290)
Outer membrane vesicle vaccines for Neisseria gonorrhoeae. [PDF]
Nat Rev Urol, 2022 Multidrug-resistant Neisseria gonorrhoeae is a global health problem, and the development of a vaccine is considered essential for the effective control of gonorrhoea. The use of outer membrane vesicle vaccines to prevent N. gonorrhoeae infection has garnered considerable interest, and a recent study using a mouse model of experimental gonococcal ...
Semchenko EA, Seib KL.
europepmc +7 more sources
Bacterial Outer Membrane Vesicles and Vaccine Applications [PDF]
Frontiers in Immunology, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of meningococcal antigens or unrelated antigens incorporated into the vesicle structure.
Acevedo, Reinaldo +10 more
openaire +8 more sources
Regulation of outer-membrane proteins (OMPs) A and F, during hlyF-induced outer-membrane vesicle (OMV) biosynthesis [PDF]
Heliyon, 2019 Background: Gram-negative bacteria actively secrete outer membrane vesicles into the surrounding environment and these vesicles have been shown to play various physiological and protective roles such as carrying antibiotic-degrading enzymes and acting as
Wouter André van der Westhuizen +3 more
doaj +3 more sources
Bacterial outer membrane vesicle biogenesis: a new mechanism and its implications [PDF]
Microbial Cell, 2016 Outer membrane vesicle (OMV) release by Gram-negative bacteria has been observed and studied for decades. First considered as a by-product of cell lysis, it soon became evident that OMVs are actively secreted from the outer membrane (OM) of Gram-negative
Sandro Roier +3 more
doaj +2 more sources
A Bilayer-Couple Model of Bacterial Outer Membrane Vesicle Biogenesis [PDF]
mBio, 2012 Gram-negative bacteria naturally produce outer membrane vesicles (OMVs) that arise through bulging and pinching off of the outer membrane. OMVs have several biological functions for bacteria, most notably as trafficking vehicles for toxins ...
Jeffrey W. Schertzer, Marvin Whiteley
doaj +2 more sources
DNA Inversion Regulates Outer Membrane Vesicle Production in Bacteroides fragilis. [PDF]
PLoS ONE, 2016 Phase changes in Bacteroides fragilis, a member of the human colonic microbiota, mediate variations in a vast array of cell surface molecules, such as capsular polysaccharides and outer membrane proteins through DNA inversion.
Haruyuki Nakayama-Imaohji +10 more
doaj +3 more sources
The Role of Virulence Proteins in Protection Conferred by Bordetella pertussis Outer Membrane Vesicle Vaccines [PDF]
Vaccines, 2020 The limited protective immunity induced by acellular pertussis vaccines demands development of novel vaccines that induce broader and longer-lived immunity.
René H. M. Raeven +11 more
doaj +2 more sources
Polymorphic Regulation of Outer Membrane Lipid A Composition [PDF]
mBio, 2016 The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and ...
Russell E. Bishop
doaj +2 more sources
Outer membrane vesicles: A bacterial-derived vaccination system
Frontiers in Microbiology, 2022 Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and ...
Linda A. Lieberman
doaj +3 more sources
Bacterial outer membrane vesicle nanorobot. [PDF]
Proc Natl Acad Sci U S AAutonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease
Tang S +15 more
europepmc +4 more sources