Results 11 to 20 of about 1,644,691 (285)
Bacterial Outer Membrane Vesicles and Vaccine Applications [PDF]
Frontiers in Immunology, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of meningococcal antigens or unrelated antigens incorporated into the vesicle structure.
Acevedo, Reinaldo +10 more
core +11 more sources
Outer membrane vesicle vaccines for Neisseria gonorrhoeae [PDF]
Nature Reviews Urology, 2021 Multidrug-resistant Neisseria gonorrhoeae is a global health problem, and the development of a vaccine is considered essential for the effective control of gonorrhoea. The use of outer membrane vesicle vaccines to prevent N. gonorrhoeae infection has garnered considerable interest, and a recent study using a mouse model of experimental gonococcal ...
Evgeny A. Semchenko, Kate L. Seib
openaire +4 more sources
Regulation of outer-membrane proteins (OMPs) A and F, during hlyF-induced outer-membrane vesicle (OMV) biosynthesis [PDF]
Heliyon, 2019 Background: Gram-negative bacteria actively secrete outer membrane vesicles into the surrounding environment and these vesicles have been shown to play various physiological and protective roles such as carrying antibiotic-degrading enzymes and acting as
Wouter André van der Westhuizen +3 more
doaj +2 more sources
Bacterial outer membrane vesicle biogenesis: a new mechanism and its implications
Microbial Cell, 2016 Outer membrane vesicle (OMV) release by Gram-negative bacteria has been observed and studied for decades. First considered as a by-product of cell lysis, it soon became evident that OMVs are actively secreted from the outer membrane (OM) of Gram-negative
Sandro Roier +3 more
doaj +2 more sources
A Bilayer-Couple Model of Bacterial Outer Membrane Vesicle Biogenesis
mBio, 2012 Gram-negative bacteria naturally produce outer membrane vesicles (OMVs) that arise through bulging and pinching off of the outer membrane. OMVs have several biological functions for bacteria, most notably as trafficking vehicles for toxins ...
Jeffrey W. Schertzer, Marvin Whiteley
doaj +2 more sources
Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells. [PDF]
PLoS Pathogens, 2017 Outer membrane vesicles are nano-sized microvesicles shed from the outer membrane of Gram-negative bacteria and play important roles in immune priming and disease pathogenesis.
Eloise J O'Donoghue +8 more
doaj +2 more sources
Human Vaccines & Immunotherapeutics, 2012 Nowadays adjuvants are extensively used as immuno-stimulatory and immuno-modulatory compounds as components of subunit and combination vaccine formulations. The adjuvants of microbial origin are more frequently used among currently used licensed or experimental adjuvants.
Arfa, Moshiri +3 more
openaire +2 more sources
Bacterial outer membrane vesicle nanorobot. [PDF]
Proc Natl Acad Sci U S AAutonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease
Tang S +15 more
europepmc +4 more sources
Frontiers in Microbiology, 2021 Membrane vesicles (MVs) are released by various prokaryotes and play a role in the delivery of various cell-cell interaction factors. Recent studies have determined that these vesicles are capable of functioning as mediators of horizontal gene transfer ...
Sharmin Aktar +20 more
doaj +1 more source
Production of Outer Membrane Vesicles and Outer Membrane Tubes by Francisella novicida [PDF]
Journal of Bacteriology, 2012 Francisella spp. are highly infectious and virulent bacteria that cause the zoonotic disease tularemia. Knowledge is lacking for the virulence factors expressed by Francisella and how these factors are secreted and delivered to host cells. Gram-negative bacteria constitutively release outer membrane vesicles (OMV), which may function in the delivery of
William D, McCaig +2 more
openaire +2 more sources