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Outer Membrane Vesicle Vaccine Platforms. [PDF]
BioDrugs, 2023 Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence factor for bacteria, helping them to survive through harsh environmental conditions. Native OMVs, naturally-released from bacteria, are produced at a level too low for vaccine manufacturing, requiring ...
Micoli F, Adamo R, Nakakana U.
europepmc +3 more sources
Outer Membrane Vesicle Induction and Isolation for Vaccine Development
Frontiers in Microbiology, 2021 Gram-negative bacteria release vesicular structures from their outer membrane, so called outer membrane vesicles (OMVs). OMVs have a variety of functions such as waste disposal, communication, and antigen or toxin delivery.
Melanie D. Balhuizen +2 more
doaj +1 more source
Bordetella pertussis and outer membrane vesicles
Pathogens and Global Health, 2022 Bordetella pertussis is the causative agent of a respiratory infection called pertussis (whooping cough) that can be fatal in newborns and infants. The pathogen produces a variety of antigenic compounds which alone or simultaneously can damage various host cells.
Çiğdem Yılmaz Çolak +1 more
openaire +3 more sources
Frontiers in Microbiology, 2021 Escherichia coli produces extracellular vesicles called outer membrane vesicles (OMVs) by releasing a part of its outer membrane. We previously reported that the combined deletion of nlpI and mlaE, related to envelope structure and phospholipid ...
Yoshihiro Ojima +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Outer membrane vesicles (OMVs) produced by Gram-negative bacteria are mediators of cell survival and pathogenesis by facilitating virulence factor dissemination and resistance to antimicrobials.
Shelby L. Reimer +7 more
doaj +1 more source
Comparison of Two Different Methods for the Extraction of Outer Membrane Vesicles from the Bordetella pertussis as a Vaccine Candidate [PDF]
Archives of Razi Institute, 2021 Despite the availability of a vaccine, pertussis is still a worldwide health problem. Outer membrane vesicles (OMVs) in gram-negative bacteria can stimulate the immune system due to several outer membrane proteins and are very good candidates in vaccine ...
M. S Soltani +4 more
doaj +1 more source
Outer Membrane Vesicle-Host Cell Interactions [PDF]
Microbiology Spectrum, 2019 ABSTRACT Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions.
Jessica D, Cecil +3 more
openaire +2 more sources
Liposomes encapsulating polymeric chitosan based vesicles - a vesicle in vesicle system for drug delivery [PDF]
, 2000 Drug delivery systems comprising vesicles prepared from one amphiphile encapsulating vesicles prepared from a second amphiphile have not been prepared previously due to a tendency of the bilayer components of the different vesicles to mix during ...
Dufès, Christine +7 more
core +3 more sources
Outer Membrane Vesicles: An Emerging Vaccine Platform
Vaccines, 2022 Vaccine adjuvants are substances that improve the immune capacity of a recombinant vaccine to a great extent and have been in use since the early 1900s; they are primarily short-lived and initiate antigen activity, mainly an inflammatory response.
Dharmendra Kashyap +8 more
openaire +3 more sources
Munc 18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites [PDF]
, 2013 Four evolutionarily conserved proteins are required for mammalian regulated exocytosis: three SNARE proteins, syntaxin, SNAP-25, and synaptobrevin, and the SM protein, Munc18-1. Here, using single-molecule imaging, we measured the spatial distribution of
Rickman, Colin +9 more
core +1 more source