Results 21 to 30 of about 84,904 (290)
Outer Membrane Vesicle Vaccine Platforms. [PDF]
BioDrugs, 2023 Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence factor for bacteria, helping them to survive through harsh environmental conditions. Native OMVs, naturally-released from bacteria, are produced at a level too low for vaccine manufacturing, requiring ...
Micoli F, Adamo R, Nakakana U.
europepmc +3 more sources
Human Vaccines & Immunotherapeutics, 2012 Nowadays adjuvants are extensively used as immuno-stimulatory and immuno-modulatory compounds as components of subunit and combination vaccine formulations. The adjuvants of microbial origin are more frequently used among currently used licensed or experimental adjuvants.
Arfa, Moshiri +3 more
openaire +2 more sources
Bacterial Outer-Membrane-Mimicking Giant Unilamellar Vesicle Model for Detecting Antimicrobial Permeability [PDF]
, 2023 The construction of bacterial outer membrane models with native lipids like lipopolysaccharide (LPS) is a barrier to understanding antimicrobial permeability at the membrane interface.
Karthika S. Nair (15203024) +2 more
core +3 more sources
MicrobiologyOpen, 2022 Gaining structural information on membrane proteins in their native lipid environment is a long‐standing challenge in molecular biology. Instead, it is common to employ membrane mimetics, which has been shown to affect protein structure, dynamics, and ...
Mohammed Mouhib, Celestine N. Chi
doaj +1 more source
Gonococcal outer membrane vesicle vaccines: bacterial population biology, clinical trials, immune profiling, and vaccine design. [PDF]
NPJ VaccinesGonorrhoea is a global health concern exacerbated by rising antimicrobial resistance. Retrospective analyses indicate that outer membrane vesicle (OMV) vaccines derived from Neisseria meningitidis (MeNZB, 4CMenB) may offer partial cross-protection ...
Gu Z +6 more
europepmc +3 more sources
Production of Outer Membrane Vesicles and Outer Membrane Tubes by Francisella novicida [PDF]
Journal of Bacteriology, 2012 Francisella spp. are highly infectious and virulent bacteria that cause the zoonotic disease tularemia. Knowledge is lacking for the virulence factors expressed by Francisella and how these factors are secreted and delivered to host cells. Gram-negative bacteria constitutively release outer membrane vesicles (OMV), which may function in the delivery of
William D, McCaig +2 more
openaire +2 more sources
Frontiers in Microbiology, 2021 Membrane vesicles (MVs) are released by various prokaryotes and play a role in the delivery of various cell-cell interaction factors. Recent studies have determined that these vesicles are capable of functioning as mediators of horizontal gene transfer ...
Sharmin Aktar +20 more
doaj +1 more source
Outer Membrane Vesicle Induction and Isolation for Vaccine Development
Frontiers in Microbiology, 2021 Gram-negative bacteria release vesicular structures from their outer membrane, so called outer membrane vesicles (OMVs). OMVs have a variety of functions such as waste disposal, communication, and antigen or toxin delivery.
Melanie D. Balhuizen +2 more
doaj +1 more source
Outer Membrane Vesicles: An Emerging Vaccine Platform
Vaccines, 2022 Vaccine adjuvants are substances that improve the immune capacity of a recombinant vaccine to a great extent and have been in use since the early 1900s; they are primarily short-lived and initiate antigen activity, mainly an inflammatory response.
Dharmendra Kashyap +8 more
openaire +3 more sources
Frontiers in Microbiology, 2021 Escherichia coli produces extracellular vesicles called outer membrane vesicles (OMVs) by releasing a part of its outer membrane. We previously reported that the combined deletion of nlpI and mlaE, related to envelope structure and phospholipid ...
Yoshihiro Ojima +7 more
doaj +1 more source