Helicobacter pylori Outer Membrane Vesicles Engage TLR2 Through NapA to Promote Epithelial Association and Inflammatory Signalling [PDF]
Journal of Extracellular VesiclesHelicobacter pylori infection is characterized by chronic gastric inflammation driven by persistent activation of innate immune signaling pathways. Outer membrane vesicles (OMVs) released by H. pylori are important mediators of host–pathogen interactions.
Mariaignacia Rubilar +6 more
doaj +3 more sources
Modular engineered outer membrane vesicles for synergistic cancer immunotherapy via PD-L1 blockade and epigenetic reprogramming [PDF]
Frontiers in ImmunologyImmune checkpoint inhibitors have significantly improved therapeutic outcomes in advanced melanoma; however, their clinical efficacy is greatly limited by low overall response rates and the primary or acquired resistance.
Longxue Guan +8 more
doaj +2 more sources
A Recombinant OMV-Based Vaccine Elicits Potent Protective Immunity Against Pseudomonas aeruginosa [PDF]
VaccinesBackground: This study aimed to construct a recombinant Pseudomonas aeruginosa outer membrane vesicle (OMV) vector vaccine delivering pcrV and compare the immunological impacts of OMVs as carriers versus as adjuvants.
Jiannan Li +9 more
doaj +2 more sources
A Randomized, Double-Blind, Placebo-Controlled Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Outer Membrane Vesicle (OMV) Platform-Based Vaccine Administered Intranasally to Healthy Adults [PDF]
VaccinesBackground: The COVID-19 pandemic exposed critical gaps in pandemic preparedness and highlighted the need for vaccine platforms capable of rapid adaptation.
Heleen Kraan +4 more
doaj +2 more sources
Angiopep-2-decorated bacterial outer membrane vesicles penetrate the blood-brain barrier for glioblastoma chemo-immunotherapy [PDF]
Drug DeliveryGlioblastoma (GBM) therapy remains one of the most formidable challenges in oncology because of the blood-brain barrier (BBB), immunosuppressive tumor microenvironment, and drug resistance.
Pir Tariq Shah +11 more
doaj +2 more sources
Does the syn- versus post-rift thickness ratio have an impact on the inversion-related structural style? [PDF]
Solid Earth, 2023 Many extensional basins worldwide are modified by subsequent compressional episodes, which lead to inverted structures. The structures associated with the reactivation of pre-existing faults are critically important in the formation of suitable ...
A. Tamas +7 more
doaj +1 more source
Wettability Changes Due to Nanomaterials and Alkali—A Proposed Formulation for EOR
Nanomaterials, 2021 We investigated the usage of two silica nanomaterials (surface-modified) and alkali in enhanced oil recovery through Amott spontaneous imbibition tests, interfacial tension (IFT) measurements, and phase behavior.
Samhar Saleh +5 more
doaj +1 more source
Sorption of Nanomaterials to Sandstone Rock
Nanomaterials, 2022 We investigated the interaction of silica nanostructured particles and sandstone rock using various experimental approaches, such as fluid compatibility, batch sorption and single-phase core-floods.
Christian Scheurer +4 more
doaj +1 more source
Linked thick- to thin-skinned inversion in the central Kirthar Fold Belt of Pakistan [PDF]
Solid Earth, 2019 The Kirthar Fold Belt is part of the transpressive transfer zone in Pakistan linking the Makran accretionary wedge with the Himalaya orogeny. The region is deforming very obliquely, nearly parallel to the regional S–N plate motion vector, indicating ...
R. Hinsch +4 more
doaj +1 more source
Inversion tectonics: a brief petroleum industry perspective [PDF]
Solid Earth, 2020 Inverted structures provide traps for petroleum exploration, typically four-way structural closures. As to the degree of inversion, based on a large number of worldwide examples seen in various basins, the most preferred petroleum exploration targets are
G. Tari +3 more
doaj +1 more source