Results 41 to 50 of about 10,092 (247)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Wind–Photovoltaic–Electrolyzer-Underground Hydrogen Storage System for Cost-Effective Seasonal Energy Storage

Energies
Photovoltaic (PV) and wind energy generation result in low greenhouse gas footprints and can supply electricity to the grid or generate hydrogen for various applications, including seasonal energy storage.
Torsten Clemens, Martin Hunyadi-Gall, Andreas Lunzer, Vladislav Arekhov, Martin Datler, Albert Gauer   +5 more
doaj   +1 more source

Incorporating risk in geothermal field development planning: applying decision-theoretic agents

Geothermal Energy
Geothermal field development requires decisions about data acquisition and the selection of an optimal development scenario (DS) under uncertainty. Effective planning must address two distinct types of risk: systematic risk, which affects the broader ...
Torsten Clemens, Anthony Corso, Maria-Magdalena Chiotoroiu, Mykel J. Kochenderfer   +3 more
doaj   +1 more source

Towards an Ontology Metadata Standard [PDF]

, 2006
In this poster, we present (i) a proposal for a metadata standard, known as Ontology Metadata Vocabulary (OMV) which is based on discussions in the EU IST thematic network of excellence Knowledge Web1 and (ii) two complementary reference implementations ...
Palma, R., Hartmann, J., Gómez-Pérez, A.   +2 more
core  

Bactericidal activity of serum from mice immunized with OMV.

, 2015
WT and ptx3-/- mice were immunized by ip or im treatment with OMV and sera were collected two weeks after the last immunization.
Alberto Mantovani (287283), Rino Rappuoli (42469), Giuseppe Mancuso (166914), Concetta Beninati (166964), Barbara Bottazzi (291673), Silvana Savino (649553), Marina Sironi (704722), Laura Santini (704719), Ana I. Dueñas Díez (704721), Livija Deban (704724), Marzia M. Giuliani (704720), Giuseppe Teti (166957), Mariagrazia Pizza (222077), Cecilia Garlanda (291677), Sonia Valentino (704723)   +14 more
core   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa

mBio, 2017
The Pseudomonas quinolone signal (PQS) is an important quorum-sensing molecule in Pseudomonas aeruginosa that also mediates its own packaging and transport by stimulating outer membrane vesicle (OMV) formation.
Catalina Florez, Julie E. Raab, Adam C. Cooke, Jeffrey W. Schertzer   +3 more
doaj   +1 more source

Effects of outer membrane vesicle formation, surface-layer production and nanopod development on the metabolism of phenanthrene by Delftia acidovorans Cs1-4. [PDF]

PLoS ONE, 2014
Nanopods are extracellular structures arising from the convergence of two widely distributed bacterial characteristics: production of outer membrane vesicles (OMV) and formation of surface layers (S-layers). Nanopod production is driven by OMV formation,
Ameesha Shetty, William J Hickey
doaj   +1 more source

Programmable three‐state nanoreactor for spatiotemporally controlled tumor therapy

BMEMat, EarlyView.
The OMVs are shielded with a biocompatible Da–Ca shell, which prolongs its circulation period and promotes intratumoral accumulation. Importantly, the biocompatible Da–Ca shell can be controllably disintegrated in tumor microenvironment by using laser irradiation, generating in situ hyperthermia and releasing Ca2+.
Guihong Lu, Peng Ye, Xiaoyan Li, Ke Ma, Chengliang Lyu, Kai Zhang, Ran Luo, Yang Ji, Shiqi Mei, Fan Zhang, Jinxie Zhang, Lin Mei, Hui Tan   +12 more
wiley   +1 more source

Proteomic Analysis of Vesicle-Producing Pseudomonas aeruginosa PAO1 Exposed to X-Ray Irradiation

Frontiers in Microbiology, 2020
Ionizing irradiation kills pathogens by destroying nucleic acids without protein structure destruction. However, how pathogens respond to irradiation stress has not yet been fully elucidated.
Li Zhang, Shi-qiao Zhao, Jie Zhang, Ying Sun, Ya-liu Xie, Yan-bin Liu, Cui-cui Ma, Bo-guang Jiang, Xue-yuan Liao, Wen-fang Li, Xing-jun Cheng, Zhen-ling Wang   +11 more
doaj   +1 more source