Results 21 to 30 of about 6,359 (195)

In silico identification and modification of T cell epitopes in pertussis antigens associated with tolerance

Human Vaccines & Immunotherapeutics, 2020
The resurgence of whooping cough since the introduction of acellular (protein) vaccines has led to a renewed interest in the development of improved pertussis vaccines; Outer Membrane Vesicles (OMVs) carrying pertussis antigens have emerged as viable ...
Corine Kruiswijk, Guilhem Richard, Merijn L.M. Salverda, Pooja Hindocha, William D. Martin, Anne S. De Groot, Elly Van Riet   +6 more
doaj   +1 more source

Comparative Analysis of Outer Membrane Vesicle Isolation Methods With an Escherichia coli tolA Mutant Reveals a Hypervesiculating Phenotype With Outer-Inner Membrane Vesicle Content

Frontiers in Microbiology, 2021
Outer membrane vesicles (OMVs) produced by Gram-negative bacteria are mediators of cell survival and pathogenesis by facilitating virulence factor dissemination and resistance to antimicrobials.
Shelby L. Reimer, Daniel R. Beniac, Shannon L. Hiebert, Timothy F. Booth, Patrick M. Chong, Garrett R. Westmacott, George G. Zhanel, Denice C. Bay   +7 more
doaj   +1 more source

Research Progress on Biological Roles and Mechanisms of Outer Membrane Vesicles Derived From Gram-negative Pathogenic Bacteria

Guangdong nongye kexue, 2023
Outer membrane vesicles (OMV) are nanoplike particles secreted by Gram-negative(G-) bacteria. OMV are spherical, bilayer membrane-like structures, mostly 20 to 250 nm in diameter. They are mainly composed of the outer membrane components of bacteria. OMV
Chunling LI, Haiyi KE, Minsheng XU, Zhibiao BIAN, Kunli ZHANG, Yan LI, Shaolun ZHAI   +6 more
doaj   +1 more source

LPS Remodeling Triggers Formation of Outer Membrane Vesicles in Salmonella

mBio, 2016
Outer membrane vesicles (OMV) are proposed to mediate multiple functions during pathogenesis and symbiosis. However, the mechanisms responsible for OMV formation remain poorly understood.
Wael Elhenawy, Michael Bording-Jorgensen, Ezequiel Valguarnera, M. Florencia Haurat, Eytan Wine, Mario F. Feldman   +5 more
doaj   +1 more source

Sodium Taurocholate Stimulates Campylobacter jejuni Outer Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway

Frontiers in Cellular and Infection Microbiology, 2019
Campylobacter jejuni outer membrane vesicles (OMVs) contain numerous virulence-associated proteins including the cytolethal distending toxin and three serine proteases. As C.
Cadi Davies, Aidan J. Taylor, Abdi Elmi, Jody Winter, Janie Liaw, Anna D. Grabowska, Ozan Gundogdu, Brendan W. Wren, David J. Kelly, Nick Dorrell   +9 more
doaj   +1 more source

Preferential Packing of Acidic Glycosidases and Proteases into Bacteroides Outer Membrane Vesicles

mBio, 2014
Outer membrane vesicles (OMV) are spherical membranous structures released from the outer membrane (OM) of Gram-negative bacteria. OMV have been proposed to play several different roles during both pathogenesis and symbiosis.
Wael Elhenawy, Mykhaylo O. Debelyy, Mario F. Feldman   +2 more
doaj   +1 more source

Antitumor effects of Escherichia coli-derived outer membrane vesicles loaded with ferrous sulfide on oral squamous cell carcinoma [PDF]

Kouqiang yixue
Objective To evaluate the therapeutic efficacy of OMV@FeS against oral squamous cell carcinoma(OSCC). Methods Escherichia coli-derived outer membrane vesicle (OMV) was extracted using ultracentrifugation and co-precipitated with FeS to form OMV@FeS.
LI Ang, GUO Shuqi, MENG Jian, SHAN Xuelong, LIU Zhen, ZHU Shenghui
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

B cell activation by outer membrane vesicles--a novel virulence mechanism.

PLoS Pathogens, 2010
Secretion of outer membrane vesicles (OMV) is an intriguing phenomenon of Gram-negative bacteria and has been suggested to play a role as virulence factors.
Maria Laura A Perez Vidakovics, Johan Jendholm, Matthias Mörgelin, Anne Månsson, Christer Larsson, Lars-Olaf Cardell, Kristian Riesbeck   +6 more
doaj   +1 more source

OpcA and PorB are novel bactericidal antigens of the 4CMenB vaccine in mice and humans

npj Vaccines, 2023
The ability of Neisseria meningitidis Outer Membrane Vesicles (OMV) to induce protective responses in humans is well established and mainly attributed to Porin A (PorA). However, the contribution of additional protein antigens to protection remains to be
Viola Viviani, Adele Fantoni, Sara Tomei, Sara Marchi, Enrico Luzzi, Margherita Bodini, Alessandro Muzzi, Marzia M. Giuliani, Domenico Maione, Jeremy P. Derrick, Isabel Delany, Mariagrazia Pizza, Alessia Biolchi, Erika Bartolini   +13 more
doaj   +1 more source