Results 51 to 60 of about 2,170,676 (267)

Synthetic bacterial vesicles combined with tumour extracellular vesicles as cancer immunotherapy

, 2021
Bacterial outer membrane vesicles (OMV) have gained attention as a promising new cancer vaccine platform for efficiently provoking immune responses. However, OMV induce severe toxicity by activating the innate immune system.
Lötvall, Jan,, Svennerholm, Kristina,, Jan Lötvall, Crescitelli, Rossella,, Lässer, Cecilia,, Inta Gribonika, Rossella Crescitelli, Kristina Svennerholm, Kyong‐Su Park, Park, Kyong-Su,, Gribonika, Inta,, Cecilia Lässer   +11 more
core   +1 more source

Bacterial membrane vesicle and its diversity

Drug Delivery System, 2021
すべての生物において細胞外小胞の存在が確認されている。その細胞外小胞の形成機構とともにその役割や生理的機能が近年ますます注目されてきている。細菌の細胞外小胞の形成には細胞死が関わり、それにより細胞外小胞の多様性が生まれることが明らかになった。
Nobuhiko Nomura, Masanori Toyofuku
openaire   +2 more sources

Proteome profiling of secreted and membrane vesicle associated proteins of an invasive and a commensal Staphylococcus haemolyticus isolate

Data in Brief, 2019
Bacterial membrane vesicles (MVs) mediate bacterial virulence by enabling secretion and long distance delivery of bacterial effector molecules. Staphylococcus haemolyticus has now been demonstrated to produce membrane vesicles (MVs).
Jorunn Pauline Cavanagh, Fatemeh Askarian, Maria Pain, Jack-Ansgar Bruun, Ilona Urbarova, Sun Nyunt Wai, Frank Schmidt, Mona Johannessen   +7 more
doaj   +1 more source

Extracellular vesicles of the Gram-positive gut symbiont Bifidobacterium longum induce immune-modulatory, anti-inflammatory effects

npj Biofilms and Microbiomes, 2023
The gut microbiota is now well known to affect the host’s immune system. One way of bacterial communication with host cells is via the secretion of vesicles, small membrane structures containing various cargo.
Noa Mandelbaum, Lihan Zhang, Shaqed Carasso, Tamar Ziv, Sapir Lifshiz-Simon, Irina Davidovich, Ishai Luz, Elliot Berinstein, Tal Gefen, Tomer Cooks, Yeshayahu Talmon, Emily P. Balskus, Naama Geva-Zatorsky   +12 more
doaj   +1 more source

Horizontal gene transfer and beyond: the delivery of biological matter by bacterial membrane vesicles to host and bacterial cells. [PDF]

Curr Opin Microbiol
Membrane vesicles (MVs) are produced in all domains of life. In eukaryotes, extracellular vesicles have been shown to mediate the horizontal transfer of biological material between cells [1].
Wen AX, Herman C.
europepmc   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Calcium/sodium exchange in purified secretory vesicles from bovine neurohypophyses [PDF]

, 1983
Purified secretory vesicles isolated from bovine neurohypophyses take up Na+ under the same circumstances where an efflux of Ca2+ takes place, suggesting a Na+/Ca2+ exchange. Potassium cannot substitute for Na+ in this process. Also, a Ca2+/Ca2+ exchange
Thorn, N. A., Saermark, T., Gratzl, Manfred   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Lipid-hybrid cell-derived biomimetic functional materials: A state-of-the-art multifunctional weapon against tumors

Materials Today Bio, 2023
Tumors are among the leading causes of death worldwide. Cell-derived biomimetic functional materials have shown great promise in the treatment of tumors. These materials are derived from cell membranes, extracellular vesicles and bacterial outer membrane
Wen-Shang Liu, Li-Li Wu, Cui-Min Chen, Hao Zheng, Jie Gao, Zheng-Mao Lu, Meng Li   +6 more
doaj   +1 more source

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source