Results 231 to 240 of about 1,073,881 (281)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Tandem receiver domain response regulator DrdR modulates swarming by controlling PilB/PilT activity in <i>Xanthomonas campestris</i>. [PDF]

mLife
Ren P, Meng J, Qin Q, Shi J, Yao J, Qi Y, Tang J, Li RF, Lu GT.   +8 more
europepmc   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Avian β-defensin 1 as an antibiotic-sparing supplement for preserving rooster semen quality and fertility during chilled storage. [PDF]

Poult Sci
Ratchamak R, Authaida S, Boonkum W, Chankitisakul V.   +3 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

DrdR Negatively Modulates the Expression of Flagellar Genes via Interaction With FleQ in Xanthomonas campestris. [PDF]

Mol Plant Pathol
Ren PD, Zheng J, Sun HY, Qi YH, Tang JL, Li RF, Lu GT.   +6 more
europepmc   +1 more source

Participation of the Transcriptional Regulator Fur in Modulating Biofilm Formation of the Salmonid Pathogen <i>Yersinia ruckeri</i>: Beyond Iron Homeostasis. [PDF]

Int J Mol Sci
Peñaloza D, Barros MJ, Cabezas-Mera F, Acuña LG, Vásquez-Arriagada P, Parra F, Queraltó C, Silva C, Díaz S, Ubilla C, Moya-Beltrán A, Silva A, Nevermann J, Parada P, Gil F, Fuentes JA, Calderón IL.   +16 more
europepmc   +1 more source

Insights Into Boar Semen Under Tropical Conditions in Smallholder Production Systems: Semen Quality, Potential Microbiota Contamination and Antimicrobial Susceptibility. [PDF]

Reprod Domest Anim
Adi YK, Prakasita VC, Wahyuni AETH.
europepmc   +1 more source

Nano-enabled disruption of bacterial virulence and communication in plant pathosystems: emerging strategies for sustainable disease management. [PDF]

Front Plant Sci
Alqahtani S.
europepmc   +1 more source