Results 201 to 210 of about 111,040 (251)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

ZnO Nanocrystals Inhibit <i>Escherichia coli</i> Biofilms by Suppressing <i>glgA</i>- and <i>gltB</i>-Dependent EPS Biosynthesis. [PDF]

Int J Nanomedicine
Tian X, Zhou C, Bai Q, Chen Y, Cai R, Lai J, Ye L, Feng W, Wang Y, Song Q, Liu T.   +10 more
europepmc   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Functional Characterisation of the Quorum-Sensing Regulator ExpR_Ecz in Modulation of Dickeya oryzae Motility and Virulence. [PDF]

Mol Plant Pathol
Liang Z, Liu H, He L, Chen Z, Gu W, Wu X, Chen Q, Wang X, Zhang LH.   +8 more
europepmc   +1 more source

Photothermal Amplification via Nanorobotic Swarming Dynamics

Advanced Science, EarlyView.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang, Lin Su, Zhengxin Yang, Yihang Jiang, Haojin Yang, Qianqian Wang, Li Zhang, Ben Wang, Jiajia Wang   +8 more
wiley   +1 more source

Insight into the relationship between type IV pilus function and biofilm formation. [PDF]

Biochem Soc Trans
Yu Y, Bauer RM, Mahdi R, Piepenbrink KH.
europepmc   +1 more source

Intestinal motility shapes spatiotemporal patterns of enterohemorrhagic <i>Escherichia coli</i> colonization and virulence gene expression in the host gut. [PDF]

Infect Immun
Dutta S, Galdamez W, Nguyen AT, Odem MA, Thompson L, Bosserman RE, Krachler AM.   +6 more
europepmc   +1 more source

Diverse Bacterial Properties Influence Dispersal Along Fungal Networks. [PDF]

J Fungi (Basel)
Regalado R, Silva MSC, Price E, Liang NW, Grunenwald CM, Sauer JD, Beebe DJ, Keller NP.   +7 more
europepmc   +1 more source

Microplastics in the seminal microenvironment of boar semen: associations with sperm motility and antimicrobial susceptibility. [PDF]

Front Vet Sci
Sorkytė Š, Byčenkienė S, Uogintė I, Pleskytė S, Šiukščius A, Virgailis M, Šiugždinienė R, Vaičiulienė G, Rekešiūtė A, Sutkevičienė N.   +9 more
europepmc   +1 more source