Results 231 to 240 of about 1,073,295 (282)

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

DrdR Negatively Modulates the Expression of Flagellar Genes via Interaction With FleQ in Xanthomonas campestris. [PDF]

Mol Plant Pathol
Ren PD, Zheng J, Sun HY, Qi YH, Tang JL, Li RF, Lu GT.   +6 more
europepmc   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Insights Into Boar Semen Under Tropical Conditions in Smallholder Production Systems: Semen Quality, Potential Microbiota Contamination and Antimicrobial Susceptibility. [PDF]

Reprod Domest Anim
Adi YK, Prakasita VC, Wahyuni AETH.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The transcription factor LafI integrates control of flagellar motility and T3SS1-mediated virulence in <i>Vibrio parahaemolyticus</i>. [PDF]

Appl Environ Microbiol
Zhong X, Zhang M, Ye J, Lu R, Xu Y, Ma Z, Zhao J, Wu W, Bai Y, Li Z, Zhang Y, Liu L, Zhou X, Yao H, Xu G, Fan F, Zhu Y, Yang M.   +17 more
europepmc   +1 more source

Phosphoenolpyruvate Carboxykinase Controls <i>Edwardsiella tarda</i> Virulence via Oxaloacetate. [PDF]

Biology (Basel)
Wu J, Yuan F, Huang Z, Huang S, Kou T, Chen X, Peng B.   +6 more
europepmc   +1 more source

Molecular Regulation of Biofilm Development in <i>Stenotrophomonas maltophilia</i>: Integrating Signal Transduction, Environmental Adaptation, and Antibiotic Resistance. [PDF]

Pathogens
Yu K, Zhao G, Zhang Q, Zhang X.
europepmc   +1 more source

Milk-derived peptone reduces EHEC virulence by inhibiting the type III secretion system. [PDF]

Virulence
Braverman D, Batushansky A, Sal-Man N.
europepmc   +1 more source