Results 81 to 90 of about 1,073,295 (282)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ecological relevance of flagellar motility in soil bacterial communities

Flagellar motility is a key bacterial trait as it allows bacteria to navigate their immediate surroundings. Not all bacteria are capable of flagellar motility, and the distribution of this trait, its ecological associations, and the life history ...
Strickland, Michael S, Ramoneda, Josep, Fierer, Noah, Bissett, Andrew, Fan, Kunkun, Strickland, Michael S., Lucas, Jane M., Chu, Haiyan   +7 more
core   +1 more source

Classification of bacterial motility using machine learning [PDF]

, 2020
Cells can display a diverse set of motility behaviors, and these behaviors may reflect a cell’s functional state. Automated, and accurate cell motility analysis is essential to cell studies where the analysis of motility pattern is required.
Ma, Yue
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Differential Dynamic Microscopy of Bacterial Motility

Physical Review Letters, 2011
4 pages, 4 figures. In this updated version we have added simulations to support our interpretation, and changed the model for the swimming speed probability distribution from log-normal to a Schulz distribution.
Wilson, Laurence G., Martinez, Vincent A., Schwarz-Linek, Jana, Tailleur, J., Pusey, Peter N., Bryant, Gary, Poon, Wilson C. K.   +6 more
openaire   +4 more sources

Effects of surface passivation on gliding motility assays [PDF]

, 2010
In this study, we report differences in the observed gliding speed of microtubules dependent on the choice of bovine casein used as a surface passivator.
Steven J Koch, Steven J. Koch, Lawrence J Herskowitz, Andy Maloney, Lawrence J. Herskowitz, Maloney Andy, Koch Steven J., Herskowitz Lawrence J.   +7 more
core   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Differential Gene Expression of Three Mastitis-Causing Escherichia coli Strains Grown under Planktonic, Swimming, and Swarming Culture Conditions

mSystems, 2016
Bacterial motility is thought to play an important role in virulence. We have previously shown that proficient bacterial swimming and swarming in vitro is correlated with the persistent intramammary infection phenotype observed in cattle. However, little
John D. Lippolis, Brian W. Brunelle, Timothy A. Reinhardt, Randy E. Sacco, Tyler C. Thacker, Torey P. Looft, Thomas A. Casey   +6 more
doaj   +1 more source

Helicobacter pylori FlhB function: the F1hB C-terminal homologue HP1575 acts as a "Spare part" to permit flagellar export when the HP0770 FlhB(CC) domain is deleted [PDF]

, 2006
In Helicobacterpylori 26695, a gene annotated HP1575 encodes a putative protein of unknown function which shows significant similarity to part of the C-terminal domain of the flagellar export protein FlhB.
K. J. Evans, N. Doherty, P. M. Sharp, R. E. Sockett, K. R. Hardie, Hardie, Kim R., Winzer, Klaus, K. Winzer, Sharp, Paul M., M. E. Wand, Wand, Matthew E., Evans, Katy J., Doherty, Neil, Sockett, R. Elizabeth   +13 more
core   +1 more source