Researchers have identified a citrus chimera with distinctive tissue origins and carotenoid profiles. It is discovered that fruit tissues develop from all three cell layers but in different proportions. A key transcription factor, MYB107, regulates β‐cryptoxanthin production by directly activating carotenoid biosynthesis genes, explaining why some ...
Chi Zhang+8 more
wiley +1 more source
Primary role of the Tol-Pal complex in bacterial outer membrane lipid homeostasis. [PDF]
Tan WB, Chng SS.
europepmc +1 more source
Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration
There are multiple therapeutic agents available for the treatment of both dry age‐related macular degeneration (AMD) and wet AMD. It is essential to continue innovation by introducing new drug delivery technologies that can incorporate those along with patient compliance and the accessibility of the technology into the early stages of research and ...
J Jesus Rodriguez‐Cruz+4 more
wiley +1 more source
Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy. [PDF]
Zhang F+11 more
europepmc +1 more source
A Multi‐Property Optimizing Generative Adversarial Network for de novo Antimicrobial Peptide Design
A Multi‐Property Optimizing Generative Adversarial Network (MPOGAN) is proposed to iteratively learn the relationship between peptides and multiple properties using a dynamically dataset. As the quality of the dataset improves, MPOGAN's ability to design antimicrobial peptides (AMPs) with multiple desired properties is enhanced.
Jiaming Liu+16 more
wiley +1 more source
Structural and Thermodynamic Insights into Bacterial Outer Membrane Lipid Signaling by the Innate Immune System [PDF]
Teresa Páramo+2 more
openalex +1 more source
Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy. [PDF]
Xia P+13 more
europepmc +1 more source
Bacterial outer membrane vesicles as drug delivery carrier for photodynamic anticancer therapy. [PDF]
Jiang Y, Zhou Z, Liu C, Wang L, Li C.
europepmc +1 more source
Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu+14 more
wiley +1 more source