Results 221 to 230 of about 172,115 (282)

Metformin‐Based Covalent Organic Frameworks With Excellent Biosafety and High Efficiency against Pathogenic Microorganisms

open access: yesAdvanced Science, EarlyView.
This work presents the first metformin‐based COFs featuring built‐in biosafety and a unique triple‐synergy mechanism. This scalable platform achieves broad‐spectrum eradication of bacteria and viruses, enabling reusable protective membranes with exceptional biocompatibility for advanced biomedical applications and personal protection.
Jia‐Yi Liu   +11 more
wiley   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

open access: yesAdvanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin   +5 more
wiley   +1 more source

Enhanced Photocatalytic Wastewater Purification and Bacterial Elimination via Copper Ion Irradiation‐Induced Modification of BiOCl

open access: yesAdvanced Science, EarlyView.
This study presents a copper ion irradiation method to achieve the modification function of BiOCl. By using high‐energy ion beams to introduce impurity ions inside the material, the intrinsic electric field of BiOCl is optimized, promoting the separation of photogenerated carriers and enhancing the photocatalytic activity.
Sihan Ma   +12 more
wiley   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

open access: yesAdvanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng   +11 more
wiley   +1 more source

Editorial Expression of Concern: Emerging role of bacterial outer membrane vesicle in gastrointestinal tract. [PDF]

open access: yesGut Pathog
Tian CM   +8 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

open access: yesAdvanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova   +4 more
wiley   +1 more source

NDM-5-carried outer membrane vesicles impair the efficacy of antibiotics against bacterial infections

open access: hybrid
Lin Li   +12 more
openalex   +1 more source

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