Results 331 to 340 of about 465,571 (364)

Physical properties of the bacterial outer membrane

Nature Reviews Microbiology, 2021
It has long been appreciated that the Gram-negative outer membrane acts as a permeability barrier, but recent studies have uncovered a more expansive and versatile role for the outer membrane in cellular physiology and viability. Owing to recent developments in microfluidics and microscopy, the structural, rheological and mechanical properties of the ...
Jiawei Sun, Steven T. Rutherford, Thomas J. Silhavy, Kerwyn Casey Huang   +3 more
openaire   +4 more sources

Assembly and Maintenance of Lipids at the Bacterial Outer Membrane

Chemical Reviews, 2020
The outer membrane of Gram-negative bacteria is essential for their survival in harsh environments and provides intrinsic resistance to many antibiotics. This membrane is remarkable; it is a highly asymmetric lipid bilayer. The inner leaflet of the outer membrane contains phospholipids, whereas the fatty acyl chains attached to lipopolysaccharide (LPS)
Emily Lundstedt, Daniel Kahne, Natividad Ruiz   +2 more
openaire   +4 more sources

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Immune modulation by bacterial outer membrane vesicles

Nature Reviews Immunology, 2015
Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane nanostructures that contain many components found within the parent bacterium. Until recently, OMVs were dismissed as a by-product of bacterial growth; however, findings within the past ...
Maria Kaparakis-Liaskos, Richard L. Ferrero   +1 more
openaire   +3 more sources

Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post-Photothermal Therapy.

Small, 2022
Tumor antigens released from tumor cells after local photothermal therapy (PTT) can activate the tumor-specific immune responses, which are critical for eliminating the residual lesions and distant metastases.
Yao Li, Kaiyue Zhang, Yao Wu, Yale Yue, Keman Cheng, Qingqing Feng, Xiaotu Ma, Jie Liang, Nana Ma, Guangna Liu, Guangjun Nie, L. Ren, Xiao Zhao   +12 more
semanticscholar   +1 more source

Engineered Bacterial Outer Membrane Vesicles as Controllable Two‐Way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy

Advances in Materials, 2022
The most immune cells infiltrating tumor microenvironment (TME), tumor‐associated macrophages (TAMs) closely resemble immunosuppressive M2‐polarized macrophages. Moreover, tumor cells exhibit high expression of CD47 “don't eat me” signal, which obstructs
Qingqing Feng, Xiaotu Ma, Keman Cheng, Guangna Liu, Yao Li, Yale Yue, Jie Liang, Lizhuo Zhang, Tianjiao Zhang, Xinwei Wang, Xiaoyu Gao, Guangjun Nie, Xiao Zhao   +12 more
semanticscholar   +1 more source

Phytochemical Engineered Bacterial Outer Membrane Vesicles for Photodynamic Effects Promoted Immunotherapy.

Nano letters (Print), 2022
Cancer vaccines are emerging as an attractive modality for tumor immunotherapy. However, their practical application is seriously impeded by the complex fabrication and unsatisfactory outcomes. Herein, we construct bacterial outer membrane vesicles (OMVs)
Wanru Zhuang, Yunfeng Wang, Yao Lei, Liping Zuo, Anqi Jiang, Guanghao Wu, Weidong Nie, Lili Huang, Haiyan Xie   +8 more
semanticscholar   +1 more source

Hybrid Vesicles Based on Autologous Tumor Cell Membrane and Bacterial Outer Membrane To Enhance Innate Immune Response and Personalized Tumor Immunotherapy.

Nano letters (Print), 2021
Tumor heterogeneity, often leading to metastasis, limits the development of tumor therapy. Personalized therapy is promising to address tumor heterogeneity.
Mei‐Zhen Zou, Zi-Hao Li, Xuefeng Bai, Chuan‐Jun Liu, Xianzheng Zhang   +4 more
semanticscholar   +1 more source

Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo

Advanced Functional Materials, 2021
The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need to develop novel approaches to address the problem of antibiotic shortage, particularly for Gram‐negative ...
Shuang Wu, Yi Huang, Jiachang Yan, Yuzhen Li, Jinfeng Wang, Yi Yan Yang, Peiyan Yuan, Xin Ding   +7 more
semanticscholar   +1 more source

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Advances in Materials, 2020
The highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming.
Shuang Qing, Chengliang Lyu, Li Zhu, Chao Pan, Shuang Wang, Feng Li, Jianghua Wang, H. Yue, Xiaoyong Gao, Rongrong Jia, Wei Wei, G. Ma   +11 more
semanticscholar   +1 more source