Results 81 to 90 of about 328,822 (337)

BUSCA: An integrative web server to predict subcellular localization of proteins [PDF]

, 2018
Here, we present BUSCA (http://busca.biocomp.unibo.it), a novel web server that integrates different computational tools for predicting protein subcellular localization.
Casadio, Rita, Fariselli, Piero, Martelli, Pier Luigi, Profiti, Giuseppe, Savojardo, Castrense   +4 more
core   +3 more sources

Bacterial Outer Membranes and Interactions with Membrane Proteins [PDF]

Biophysical Journal, 2015
Because the bacteria's outer membrane (OM) acts as an effective barrier against the permeation of both hydrophobic and hydrophilic compounds, gram-negative cell permeation is one of the biggest challenges to the discovery of novel antibiotics for bacterial infections and antibiotic resistance worldwide.
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Complement-mediated killing of Escherichia coli by mechanical destabilization of the cell envelope

The EMBO Journal
Complement proteins eliminate Gram-negative bacteria in the blood via the formation of membrane attack complex (MAC) pores in the outer membrane. However, it remains unclear how outer membrane poration leads to inner membrane permeation and cell lysis ...
Georgina Benn, Christian Bortolini, David M Roberts, Alice L B Pyne, Séamus Holden, Bart W Hoogenboom   +5 more
doaj   +1 more source

Bacterial outer membrane vesicle biogenesis: a new mechanism and its implications

Microbial Cell, 2016
Outer membrane vesicle (OMV) release by Gram-negative bacteria has been observed and studied for decades. First considered as a by-product of cell lysis, it soon became evident that OMVs are actively secreted from the outer membrane (OM) of Gram-negative
Sandro Roier, Franz G. Zingl, Fatih Cakar, Stefan Schild   +3 more
doaj   +1 more source

Membrane proteins and proteomics: Love is possible, but so difficult [PDF]

, 2009
Despite decades of extensive research, the large-scale analysis of membrane proteins remains a difficult task. This is due to the fact that membrane proteins require a carefully balanced hydrophilic and lipophilic environment, which optimum varies with ...
Adessi, Aebersold, Aivaliotis, Aivaliotis, Alla, Ames, Babu, Bagshaw, Bell, Berlanda-Scorza, Berven, Bierczynska-Krzysik, Bisle, Bjellqvist, Bunai, Bunai, Burré, Buxbaum, Casey, Chevallet, Chevallet, Connolly, Coughenour, Cutillas, Devreese, Eravci, Everberg, Felsted, Ferro, Gatlin, Ghosh, Gyenes, Görg, Hagan, Hahne, Hartinger, Helling, Henningsen, Henzel, Hisabori, Hjelmeland, Huang, Huang, James, Jun, Lasonder, Lescuyer, Liberatori, Lopez, Low, Luche, Lyubimova, Lüddens, MacFarlane, MacFarlane, Matsudaira, McDonough, Miguet, Moebius, Molloy, Molloy, Nandakumar, Natera, Navarre, Ong, Papasotiriou, Pappin, Patton, Pedersen, Peng, Perdew, Phadke, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rais, Rubin, Santoni, Santoni, Schindler, Schirle, Schägger, Siroy, Speers, Sweetnam, Switzer, Tastet, Taylor, Towbin, Veith, Washburn, Werner, Wilkins, Williams, Williams, Williams, Wittig, Witzmann, Wu, Yates, Ying, Zahedi   +103 more
core   +5 more sources

Small and mighty: adaptation of superphylum Patescibacteria to groundwater environment drives their genome simplicity. [PDF]

, 2020
BackgroundThe newly defined superphylum Patescibacteria such as Parcubacteria (OD1) and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment, lake, and other aquifer environments.
Adams, Benjamin G, Alm, Eric J, Arkin, Adam P, Detienne, Brittny L, Fields, Matthew W, Gao, Shuhong, Hazen, Terry C, He, Zhili, Joyner, Dominique C, Klingeman, Dawn M, Lowe, Kenneth A, Ning, Daliang, Rocha, Andrea M, Shi, Weiling, Spencer, Sarah J, Stahl, David A, Tian, Renmao, Wu, Linwei, Yang, Yunfeng, Zhang, Ping, Zhang, Ya, Zhou, Jizhong   +21 more
core   +2 more sources

The structure of bacterial outer membrane proteins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002
Integral membrane proteins come in two types, alpha-helical and beta-barrel proteins. In both types, all hydrogen bonding donors and acceptors of the polypeptide backbone are completely compensated and buried while nonpolar side chains point to the membrane. The alpha-helical type is more abundant and occurs in cytoplasmic (or inner) membranes, whereas
openaire   +3 more sources

The bacterial outer membrane β‐barrel assembly machinery [PDF]

Protein Science, 2012
Abstractβ‐Barrel proteins found in the outer membrane of Gram‐negative bacteria serve a variety of cellular functions. Proper folding and assembly of these proteins are essential for the viability of bacteria and can also play an important role in virulence.
Kelly H, Kim, Suraaj, Aulakh, Mark, Paetzel   +2 more
openaire   +2 more sources

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source