Results 31 to 40 of about 148,445 (252)
Frontiers in Microbiology, 2021 Antibiotic–adjuvant combinatory therapy serves as a viable treatment option in addressing antibiotic resistance in the clinical setting. This study was carried out to assess and characterize the adjuvant potential and mode of action of linalool against ...
Shun-Kai Yang +7 more
doaj +1 more source
Interactions between folding factors and bacterial outer membrane proteins [PDF]
Molecular Microbiology, 2005 SummaryThe outer membrane is the first line of contact between Gram‐negative bacteria and their external environment. Embedded in the outer membrane are integral outer membrane proteins (OMPs) that perform a diverse range of tasks. OMPs are synthesized in the cytoplasm and are translocated across the inner membrane and probably diffuse through the ...
Mogensen, Jesper E., Otzen, Daniel E.
openaire +3 more sources
Journal of Pharmaceutical Analysis, 2021 Mining of plant-derived antimicrobials is the major focus at current to counter antibiotic resistance. This study was conducted to characterize the antimicrobial activity and mode of action of linalyl anthranilate (LNA) against carbapenemase-producing ...
Shun-Kai Yang +5 more
doaj +1 more source
The structure of bacterial outer membrane proteins
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002 Integral membrane proteins come in two types, alpha-helical and beta-barrel proteins. In both types, all hydrogen bonding donors and acceptors of the polypeptide backbone are completely compensated and buried while nonpolar side chains point to the membrane. The alpha-helical type is more abundant and occurs in cytoplasmic (or inner) membranes, whereas
openaire +3 more sources
Folding of a bacterial integral outer membrane protein is initiated in the periplasm [PDF]
Nature Communications, 2017 AbstractThe Bam complex promotes the insertion of β-barrel proteins into the bacterial outer membrane, but it is unclear whether it threads β-strands into the lipid bilayer in a stepwise fashion or catalyzes the insertion of pre-folded substrates.
Rakesh Sikdar +3 more
openaire +3 more sources
Construction of a bacterial surface display system based on outer membrane protein F
Microbial Cell Factories, 2019 Background Bacterial surface display systems were developed to surface expose heterologous proteins or peptides for different applications, such as peptide libraries screening and live bacterial vaccine design.
Tingting Chen +12 more
doaj +1 more source
Assembly of β-barrel proteins into bacterial outer membranes
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014 Membrane proteins with a β-barrel topology are found in the outer membranes of Gram-negative bacteria and in the plastids and mitochondria of eukaryotic cells. The assembly of these membrane proteins depends on a protein folding reaction (to create the barrel) and an insertion reaction (to integrate the barrel within the outer membrane).
Selkrig, Joel +3 more
openaire +3 more sources
Structure and function of bacterial outer membrane proteins: barrels in a nutshell [PDF]
Molecular Microbiology, 2000 The outer membrane protects Gram‐negative bacteria against a harsh environment. At the same time, the embedded proteins fulfil a number of tasks that are crucial to the bacterial cell, such as solute and protein translocation, as well as signal transduction.
Koebnik, Ralf +2 more
openaire +3 more sources
The Landscape of Pseudomonas aeruginosa Membrane-Associated Proteins
Cells, 2020 Background: Pseudomonas aeruginosa cell envelope-associated proteins play a relevant role in infection mechanisms. They can contribute to the antibiotic resistance of the bacterial cells and be involved in the interaction with host cells.
Sara Motta +7 more
doaj +1 more source
Reconstitution of a nanomachine driving the assembly of proteins into bacterial outer membranes [PDF]
Nature Communications, 2014 In biological membranes, various protein secretion devices function as nanomachines, and measuring the internal movements of their component parts is a major technological challenge. The translocation and assembly module (TAM) is a nanomachine required for virulence of bacterial pathogens. We have reconstituted a membrane containing the TAM onto a gold
Shen, Hsin-Hui +12 more
openaire +3 more sources