Results 41 to 50 of about 903,825 (302)

Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. [PDF]

, 2020
Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of
Gao, Li, Ho, Sunita P, Kamarajan, Pachiyappan, Kang, Misun, Kapila, Yvonne L, Kuraji, Ryutaro, Le, Charles, Martinez, April, Rangé, Hélène, Reza Sailani, M, Ye, Changchang, Zhan, Ling, Zhang, Martin Jinye   +12 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms [PDF]

, 2017
The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria.
Bernaerts, Kristel, Boon, Nico, Pauwels, Martine, Quirynen, Marc, Rodriguez Herrero, Esteban, Slomka, Vera, Teughels, Wim   +6 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Life Identification Number (LIN) codes for the genomic taxonomy of Corynebacterium diphtheriae strains

Genome Medicine
Background Corynebacterium diphtheriae, the causative agent of diphtheria, remains a public health concern, especially in regions with low vaccination coverage.
Jose F. Delgado-Blas, Martin Rethoret-Pasty, Sylvain Brisse   +2 more
doaj   +1 more source

Risk and determinants of mortality associated with invasive group A streptococcus (iGAS) disease in Scotland: A national surveillance study

International Journal of Infectious Diseases
Objectives: Understanding determinants of mortality in invasive Group A Streptococcal (iGAS) infections is essential for developing targeted public health measures and improving clinical management.
Ebrahim Ghaderi, Eisin McDonald, Hazel Henderson, Melissa Llano, Diane Lindsay, Morris C. Muzyamba, Navneet Rai, Peter MacPherson   +7 more
doaj   +1 more source

Myo-Inositol as a carbon substrate in Francisella and insights into the metabolism of Francisella sp. strain W12-1067

International Journal of Medical Microbiology, 2020
Recently, a new environmental Francisella strain, Francisella sp. strain W12-1067, has been identified in Germany. This strain is negative for the Francisella pathogenicity island (FPI) but exhibits a putative alternative type VI secretion system.
Fan Chen, Kristin Köppen, Kerstin Rydzewski, Rosa Einenkel, Clara Morguet, Duc Tung Vu, Wolfgang Eisenreich, Klaus Heuner   +7 more
doaj   +1 more source

Bacterial ‘Cell’ Phones: Do cell phones carry potential pathogens? [PDF]

, 2009
Cell phones are important companions for professionals especially health care workers (HCWs) for better communication in hospital. The present study compared the nature of the growth of potentially pathogenic bacterial flora on cell phones in hospital ...
Bairy, I, Bhate, P, Chawla, K, Gurung, B, Mukhopadhayay, C   +4 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source