Results 81 to 90 of about 903,825 (302)

The global Mycobacterium chimaera outbreak

Microbiologia Medica, 2019
Infections due to Mycobacterium chimaera associated with a heater-cooler device used during the open-heart surgery have been reported worldwide. These cases represent the first outbreak caused by a non-tuberculous mycobacterium at a global level. Salient
Enrico Tortoli
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Complete genome and plasmid sequence, and chemotaxonomic analysis of Francisella sp. strain W12-1067, now designated as Allofrancisella heilbronnii

BMC Microbiology
Background The zoonotic pathogen Francisella tularensis is the etiological agent of tularemia. Tularemia in humans is mainly caused by F. tularensis subspecies tularensis and holarctica, but beneath some opportunistic Francisella species, like F ...
Kristin Köppen, Kerstin Rydzewski, Klaus Heuner   +2 more
doaj   +1 more source

Bacteriology of select aquatic hosts utilized in lunar sample exposure studies Final report [PDF]

Procedures and immunofluorescent techniques for screening Apollo aquatic test animals for bacterial pathogens after lunar sample ...
Lewis, D. H.
core   +1 more source

Subversion of host innate immunity by uropathogenic Escherichia coli [PDF]

, 2016
Uropathogenic Escherichia coli (UPEC) cause the majority of community-onset urinary tract infections (UTI) and represent a major etiologic agent of healthcare-associated UTI.
Cavalieri, Godaly, Hagberg, Hedges, Schappert, Shahin   +5 more
core   +3 more sources

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Comparison of Illumina and Oxford Nanopore Technology systems for the genomic characterization of Streptococcus pneumoniae

Microbiology Spectrum
Whole-genome sequencing (WGS) is an invaluable tool that enables high-resolution genotyping to precisely identify bacterial strains. It is particularly significant for highly pathogenic bacteria such as Streptococcus pneumoniae, a worldwide leading cause
Fatima Dakroub, Fata Akl, Alissar Zaghlout, Jose Rita Gerges, Nancy Hourani, Celina F. Boutros, George F. Araj, Ghassan M. Matar, Antoine Abou Fayad, Ghassan S. Dbaibo   +9 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics [PDF]

, 2019
Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment.
Coenye, Tom, Crabbé, Aurélie, Daled, Simon, Deforce, Dieter, Dhaenens, Maarten, Ostyn, Lisa, Rigauts, Charlotte, Risseeuw, Martijn, Staelens, Sorien, Van Acker, Heleen, Van Calenbergh, Serge   +10 more
core   +6 more sources

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source