Results 51 to 60 of about 1,616,748 (350)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia

American Journal of Respiratory and Critical Care Medicine, 2021
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence.
C. Pickens, C. Gao, M. Cuttica, Sean B. Smith, L. Pesce, R. Grant, M. Kang, L. Morales-Nebreda, Avni A Bavishi, J. Arnold, A. Pawlowski, Chao Qi, G. S. Budinger, Benjamin D. Singer, R. Wunderink   +14 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Accuracy of the diagnosis of pneumonia in Canadian pediatric emergency departments: A prospective cohort study.

PLoS ONE
BackgroundThe diagnosis of pediatric pneumonia and determination of the likely pathogen are complicated as the clinical picture overlaps with other respiratory illnesses, interpretation of radiographs is subjective, and laboratory results are rarely ...
Joan L Robinson, James D Kellner, Jennifer Crotts, Gabino Travassos, Guanmin Chen, Valerie G Kirk, Martin Pusic, Martin Reed, Sarah Reid, Michael Weinstein, Ravi Bhargava, Maala Bhatt, Kathy Boutis, Sarah Curtis, Serge Gouin, Tim Lynch, Richard van Wylick, David W Johnson   +17 more
doaj   +1 more source

Assessment of nasopharyngeal Streptococcus pneumoniae colonization does not permit discrimination between Canadian children with viral and bacterial respiratory infection: a matched-cohort cross-sectional study

BMC Infectious Diseases, 2021
Background Readily-available diagnostics do not reliably discriminate between viral and bacterial pediatric uncomplicated pneumonia, both of which are common.
Jeffrey M. Pernica, Kristin Inch, Haifa Alfaraidi, Ania Van Meer, Redjana Carciumaru, Kathy Luinstra, Marek Smieja   +6 more
doaj   +1 more source

Expression and significance of serum vitamin D and LL-37 levels in infants with bacterial pneumonia

Frontiers in Pediatrics, 2022
ObjectiveTo investigate the significance of vitamin D and human antimicrobial peptide LL-37 in the occurrence and development of bacterial pneumonia in infants.MethodsFrom January 2021 to January 2022, 80 infants with bacterial pneumonia were selected ...
Shaojie Zhao, Shaojie Zhao, Yixiu He, Menglan Pan, Bingzhang Chen, Siqi Zhang, Yufeng Zhang, Yafei Zhu   +7 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Immune persistence of a single dose of 23-valent pneumococcal polysaccharide vaccine: A 6-year follow-up

Human Vaccines & Immunotherapeutics
In a previous phase 3 clinical trial, a 23-valent pneumococcal polysaccharide vaccine (PPV23) induced robust immune responses in participants aged 2 years and older.
Lili Huang, Xinyi Yang, Hong Li, Zhiqiang Xie, Taotao Zhu, Wangyang You, Zeng Wang, Jiebing Tan, Guangwei Feng, Qingmin Sun, Bin Wang, Xing Han, Yanxia Wang   +12 more
doaj   +1 more source

A comparison of demographic, epidemiological and clinical characteristics of hospital influenza-related viral pneumonia patients

BMC Infectious Diseases, 2021
Background Through the comparison of the demographic, epidemiological, and clinical characteristics of hospital human influenza (influenza A (H1N1) pdm09, H3N2, and B)-related and hospitalized avian-origin influenza A (H7N9)-related viral pneumonia ...
Bin Fu, Zhengjie Wu, Lingtong Huang, Zhaohui Chai, Peidong Zheng, Qinmiao Sun, Silan Gu, Qiaomai Xu, Haiting Feng, Lingling Tang   +9 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source