Results 61 to 70 of about 1,206,208 (293)

Expression and significance of serum vitamin D and LL-37 levels in infants with bacterial pneumonia

Frontiers in Pediatrics, 2022
ObjectiveTo investigate the significance of vitamin D and human antimicrobial peptide LL-37 in the occurrence and development of bacterial pneumonia in infants.MethodsFrom January 2021 to January 2022, 80 infants with bacterial pneumonia were selected ...
Shaojie Zhao, Shaojie Zhao, Yixiu He, Menglan Pan, Bingzhang Chen, Siqi Zhang, Yufeng Zhang, Yafei Zhu   +7 more
doaj   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

eLife, 2014
To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections.
Zhiping Yang, Yuh-Chin T Huang, Henry Koziel, Rini de Crom, Hartmut Ruetten, Paulus Wohlfart, Reimar W Thomsen, Johnny A Kahlert, Henrik Toft Sørensen, Szczepan Jozefowski, Amy Colby, Lester Kobzik   +11 more
doaj   +1 more source

The effects of vitamin D supplementation on the incidence of pneumonia in infants and young children in Kabul, Afghanistan: a double blind randomized controlled trial [PDF]

Afghanistan has one of the highest infant mortalities in the world, and pneumonia is one of the main killers. Moreover, Dietary intake of vitamin D is low and exposure to sunlight is limited due to widespread use of Burqa by women.
Maroof, Zabihullah
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Pneumonia hospitalizations of children aged <2 years in Poland before (2013–2016) and after (2017–2018) universal mass vaccination with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine

Human Vaccines & Immunotherapeutics, 2022
As infection with Streptococcus pneumoniae is an important cause of pneumonia in children, the World Health Organization recommends childhood pneumococcal conjugate vaccines (PCVs).
Amit Bhavsar, Janusz Zaryczański, Anna Wasilewska, Delphine Saragoussi, Raghavendra Devadiga, Chris Colby, Enas Bahar, Jacek Wysocki   +7 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Diagnostic and prognostic value of serum HBP combined with PCT, CRP, and SAA in early-stage pneumonia

Virology Journal
Objective To assess the diagnostic efficacy of serum heparin-binding protein (HBP) as a standalone biomarker and in combination panels for distinguishing early-stage bacterial from viral pneumonia, and to explore its prognostic value in predicting ...
Pengju Cao, Songgao Zhang, Jiangang Huang, Wanru Dai   +3 more
doaj   +1 more source