Results 111 to 120 of about 7,784,271 (373)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Comparative NanoUPLC-MSE analysis between magainin I-susceptible and -resistant Escherichia coli strains

Scientific Reports, 2017
In recent years the antimicrobial peptides (AMPs) have been prospected and designed as new alternatives to conventional antibiotics. Indeed, AMPs have presented great potential toward pathogenic bacterial strains by means of complex mechanisms of action.
Marlon H. Cardoso, Keyla C. de Almeida, Elizabete de S. Cândido, André M. Murad, Simoni C. Dias, Octávio L. Franco   +5 more
doaj   +1 more source

Signal recognition particle prevents N-terminal processing of bacterial membrane proteins

Nature Communications, 2017
Bacterial proteins are synthesized with an N-formylated amino-terminal methionine, and N-formylated peptides elicit innate-immunity responses against bacterial infections.
Amitabh Ranjan, Evan Mercier, A. Bhatt, W. Wintermeyer   +3 more
semanticscholar   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Exploitation of host polyubiquitination machinery through molecular mimicry by eukaryotic-like bacterial F-box effectors

Frontiers in Cellular and Infection Microbiology, 2010
Microbial pathogens have evolved exquisite mechanisms to interfere and intercept host biological processes, often through molecular mimicry of specific host proteins.
Yousef eAbu Kwaik, Christopher T. Price
doaj   +1 more source

A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis [PDF]

, 2011
Background: Bacterial exported proteins represent key components of the host-pathogen interplay. Hence, we sought to implement a combined approach for characterizing the entire exoproteome of the pathogenic bacterium Corynebacterium pseudotuberculosis,
Azevedo, Vasco, Carvalho, Maria A. R., Castro, Thiago L. P., Dowson, Christopher G., Farias, Luiz M., Meyer, Roberto, Miyoshi, Anderson, Oliveira, Sérgio C., Pacheco, Luis G. C., Pimenta, Adriano M. C., Santos, Agenor V., Santos, Anderson R., Santos, Simone G., Scrivens, James H., Seyffert, Núbia, Silva, Artur, Silva, Wanderson M., Slade, Susan E.   +17 more
core   +4 more sources

Bacterial Protein-Tyrosine Kinases [PDF]

Current Proteomics, 2010
Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial enzymes that are unique in exploiting the ATP/GTP-binding ...
Shi, Lei, Kobir, Ahasanul, Jers, Carsten, Mijakovic, Ivan   +3 more
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage [PDF]

, 2019
Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses.
CJ Adler, C Warinner, C Warinner, S Buckley, IM Velsko, J Hendy, ID Mandel, C Warinner, C Walker, V Zijnge, P Ramberg, D Belstrøm, PE Kolenbrander, WG Wade, SS Socransky, IM Velsko, SC Holt, M Umeda, BH Mullally, JW Lee, IM Velsko, LM Shaddox, AW Aruni, KL Cross, L Albayrak, S Yost, VM Barnes, JL Ebersole, S Yost, P Jorth, A Basic, RR Jersie-Christensen, T Imamura, LS Weyrich, AA Ribeiro, EL Gross, A Simón-Soro, Zachary D. Moye, O Manor, SM Dabdoub, D Belstrøm, RC Page, S Hillson, A Ogden, S Brooks, JL Buckberry, D Ferembach, CO Lovejoy, TW Phenice, LAF Frantz, P Skoglund, P Skoglund, M. Meyer, A Ginolhac, H Jónsson, A Peltzer, M Schubert, H Li, H Li, M Meyer, D Knights, N Segata, DT Truong, DH Parks, DH Parks, M Bastian, R Overbeek, DH Huson, MC Chambers, FE Dewhirst   +69 more
core   +4 more sources

EffectiveDB—updates and novel features for a better annotation of bacterial secreted proteins and Type III, IV, VI secretion systems

Nucleic Acids Res., 2015
Protein secretion systems play a key role in the interaction of bacteria and hosts. EffectiveDB (http://effectivedb.org) contains pre-calculated predictions of bacterial secreted proteins and of intact secretion systems.
Valerie Eichinger, T. Nussbaumer, A. Platzer, Marc-André Jehl, Roland Arnold, T. Rattei   +5 more
semanticscholar   +1 more source