Results 111 to 120 of about 3,299,929 (298)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Extractable Bacterial Surface Proteins in Probiotic–Host Interaction

Frontiers in Microbiology, 2018
Some Gram-positive bacteria, including probiotic ones, are covered with an external proteinaceous layer called a surface-layer. Described as a paracrystalline layer and formed by the self-assembly of a surface-layer-protein (Slp), this optional structure
Fillipe L. R. do Carmo, Fillipe L. R. do Carmo, Houem Rabah, Houem Rabah, Rodrigo D. De Oliveira Carvalho, Floriane Gaucher, Floriane Gaucher, Barbara F. Cordeiro, Sara H. da Silva, Yves Le Loir, Vasco Azevedo, Gwénaël Jan   +11 more
doaj   +1 more source

Formyl-methionine as a degradation signal at the N-termini of bacterial proteins

, 2015
In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. The fMet residue is cotranslationally deformylated by a ribosome-associated deformylase.
Tri T. M. Vu, Alexander Varshavsky, Konstantin I. Piatkov, Cheol-Sang Hwang   +3 more
core   +1 more source

Protein Aggregation Profile of the Bacterial Cytosol

PLoS ONE, 2010
Protein misfolding is usually deleterious for the cell, either as a consequence of the loss of protein function or the buildup of insoluble and toxic aggregates. The aggregation behavior of a given polypeptide is strongly influenced by the intrinsic properties encoded in its sequence.
Sánchez de Groot, Natalia, Ventura, Salvador   +1 more
openaire   +5 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Recruitment of Vitronectin by Bacterial Pathogens: A Comprehensive Overview

Microorganisms
The key factor that enables pathogenic bacteria to establish successful infections lies largely in their ability to escape the host’s immune response and adhere to host surfaces.
Angelica Pellegrini, Giampiero Pietrocola   +1 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Deciphering interplay between Salmonella invasion effectors. [PDF]

, 2008
Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells.
Robert J Cain, Koronakis, Vassilis, Cain Robert J., Hayward, RD, Koronakis, V, Hayward, Richard D, Richard D Hayward, Isberg, R.R., Hayward, Richard D., Koronakis, V., Vassilis Koronakis, Cain, Robert J, Cain, RJ, Hayward Richard D., Cain, R.J., Koronakis Vassilis   +15 more
core   +2 more sources