Bacterial polysaccharide–protein conjugate vaccines [PDF]
Following demonstration that chemical conjugation of polysaccharide antigens to proteins could enhance their immunogenicity in the 1920s, interest in this approach to primary prevention of bacterial infections waned with the development and widespread use of antibiotics. Emergence of resistant bacteria rekindled interest in the late 20th century, which
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Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs [PDF]
Kerstin Skovgaard +6 more
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Functional Determinants of a Small Protein Controlling a Broadly Conserved Bacterial Sensor Kinase [PDF]
Srujana S. Yadavalli +8 more
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
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Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins [PDF]
Nicholas J. Dickens +2 more
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Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
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RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus. [PDF]
Chiang-Ni C +7 more
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Recent Patents on Bacterial Proteins as Potential Anticancer Agents [PDF]
Arsénio M. Fialho +1 more
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SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
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