Results 201 to 210 of about 824,613 (260)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Bioinformatic Resistome Profiling of Metal Tolerance Mechanisms in Endodontic Infections: Implications for Antimicrobial Nanoparticle-Based Biomaterials. [PDF]

J Funct Biomater
Luna-Lara CA, Luna-Dominguez CR, Oliver-Parra R, Criollo-Barrios OV, Vaca-Jasso MLD, Salas-Orozco MF.   +5 more
europepmc   +1 more source

Bacterial Acyl Carrier Proteins Are a Cytoplasmic Target for Different Cationic Antimicrobial and Antibiofilm Peptides. [PDF]

Int J Mol Sci
Ramamourthy G, Paul S, Jalal IM, Ishida H, Vogel HJ.   +4 more
europepmc   +1 more source

<i>Shigella flexneri</i>-Encoded E3 Ubiquitin Ligase IpaH2 Reveals Plakophilin-2 as a Host Restriction Factor for Sindbis Virus. [PDF]

Int J Mol Sci
Embry A, Rex EA, Schad DF, Deng DM, Alto NM, Gammon DB.   +5 more
europepmc   +1 more source

Functional Characterization of a Putative Sortase FA1364 in <i>Filifactor alocis</i>. [PDF]

Int J Mol Sci
Mishra A, Sakyi Opoku NY, Zhang G, Lamont RJ, Fletcher HM.   +4 more
europepmc   +1 more source

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Bacterial Protein Kinases

2021
Bacteria are able to inhabit and survive vastly diverse environments. This enormous adaptive capacity depend on their ability to perceive cues from the micro-environment and process this information accordingly to mount appropriate metabolic responses and ultimately sustain homeostasis.
openaire   +2 more sources

Bacterial Moonlighting Proteins and Bacterial Virulence

2011
Implicit in the central dogma is the hypothesis that each protein gene product has but one function. However, over the past decade, it has become clear that many proteins have one or more unique functions, over-and-above the principal biological action of the specific protein.
Brian, Henderson, Andrew, Martin
openaire   +2 more sources