Results 71 to 80 of about 1,243,937 (259)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nicorandil reduces the antimicrobial effectiveness of polymyxin E against Klebsiella pneumoniae by decreasing reactive oxygen species accumulation

Frontiers in Cellular and Infection Microbiology
Nitric oxide (NO) plays a crucial role in bacterial physiology and survival, particularly in relation to antibiotic resistance. The protective role of NO against antibiotics is intricate, and the potential antagonistic interactions between NO donors and ...
Rongqing Zhu, Fangxin Luo, Chenxi Yuan, Ziqian Fang, Yaqin Guo, Bao Meng, Dongmei Zhao, Yanyan Liu, Yanyan Liu, Yanyan Liu, Yi Yang, Yi Yang, Yi Yang, Yasheng Li, Yasheng Li, Yasheng Li, Jiabin Li, Jiabin Li, Jiabin Li, Liang Yu, Liang Yu, Liang Yu   +21 more
doaj   +1 more source

Antimicrobial Resistance, Genetic Diversity and Multilocus Sequence Typing of Escherichia coli from Humans, Retail Chicken and Ground Beef in Egypt

Pathogens, 2020
Contamination of retail foods with foodborne pathogens, particularly the antimicrobial resistant ones, poses a persistent threat to human health. There is a dearth of information about the overlapping Escherichia coli (E. coli) lineages circulating among
Hazem Ramadan, Charlene R. Jackson, Jonathan G. Frye, Lari M. Hiott, Mohamed Samir, Amal Awad, Tiffanie A. Woodley   +6 more
doaj   +1 more source

Moroccan propolis: a natural antioxidant, antibacterial, and antibiofilm against Staphylococcus aureus with no induction of resistance after continuous exposure [PDF]

, 2018
This study was performed to evaluate the total phenols, flavonoids, and antioxidant activities of twenty-four propolis samples from different regions of Morocco.
AAZZA, Smail, Bankova, Vassya, EL-GEUNDOUZ, Soukaina, Faleiro, Maria Leonor, Lyoussi, Badiaa, Miguel, Maria, Neto, Luís, Popova, Milena   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection

Journal of Nanobiotechnology
Bacterial cystitis, a commonly occurring urinary tract infection (UTI), is renowned for its extensive prevalence and tendency to recur. Despite the extensive utilization of levofloxacin as a conventional therapeutic approach for bacterial cystitis, its ...
Yi Yang, Guang-Wei Yang, Jian-Juan Lu, Hao-Ran Chen, Ya-Qin Guo, Ning Yang, Yun-Zhu Zhu, Xiao-Qiang Liu, Ting-Ting Su, Yan-Yan Liu, Liang Yu, Ya-Sheng Li, Li-Fen Hu, Jia-Bin Li   +13 more
doaj   +1 more source

Gene transfer in the GI tract and oral cavity [PDF]

, 2000
Gene transfer is important in spreading antibiotic resistance and other traits such as virulence factors. In this review the molecular mechanisms of gene transfer are outlined and the biological consequences of bacterial gene transfer in the GI tract and
Mullany, P
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Designing phage cocktails to combat the emergence of bacteriophage-resistant mutants in multidrug-resistant Klebsiella pneumoniae

Microbiology Spectrum
Phage therapy, an emerging strategy in the fight against recalcitrant bacterial infections, encounters a significant hurdle posed by the development of phage-resistant bacterial strains. To address this concern, we suggest a novel phage cocktail.
Seongjun Yoo, Kang-Mu Lee, Nayoung Kim, Thao Nguyen Vu, Ricardo Abadie, Dongeun Yong   +5 more
doaj   +1 more source