Results 51 to 60 of about 1,461,971 (329)

A widespread family of polymorphic toxins encoded by temperate phages

BMC Biology, 2017
Background Polymorphic toxins (PTs) are multi-domain bacterial exotoxins belonging to distinct families that share common features in terms of domain organization.
Anne Jamet, Marie Touchon, Bruno Ribeiro-Gonçalves, João André Carriço, Alain Charbit, Xavier Nassif, Mario Ramirez, Eduardo P. C. Rocha   +7 more
doaj   +1 more source

Inhibiting bacterial toxins by channel blockage. [PDF]

Pathog Dis, 2016
Bezrukov SM, Nestorovich EM.
europepmc   +2 more sources

Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease

Toxins, 2020
Several of the uremic toxins, which are difficult to remove by dialysis, originate from the gut bacterial metabolism. This opens opportunities for novel targets trying to decrease circulating levels of these toxins and their pathophysiological effects ...
Griet Glorieux, Tessa Gryp, Alessandra Perna   +2 more
doaj   +1 more source

The Biological Properties of Bacterial Toxins

Вестник войск РХБ защиты
Knowledge of the biological properties of bacterial toxins is constantly being updated. Over the past two decades, the research interest has shifted from natural toxins to their genetically modified derivatives.
M. V. Supotnitskiy
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

AB₅ Enterotoxin-Mediated Pathogenesis: Perspectives Gleaned from Shiga Toxins

Toxins, 2022
Foodborne diseases affect an estimated 600 million people worldwide annually, with the majority of these illnesses caused by Norovirus, Vibrio, Listeria, Campylobacter, Salmonella, and Escherichia coli. To elicit infections in humans, bacterial pathogens
Erika N. Biernbaum, Indira T. Kudva
doaj   +1 more source

Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins

Toxins, 2018
Bacterial pore-forming toxins induce a rapid and massive increase in cytosolic Ca2+ concentration due to the formation of pores in the plasma membrane and/or activation of Ca2+-channels.
S. Bouillot, E. Reboud, P. Huber
semanticscholar   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection

Toxins, 2018
For many of the most important human bacterial infections, invasive disease severity is fueled by the cell damaging and pro-inflammatory effects of secreted pore-forming toxins (PFTs).
Tamara Escajadillo, V. Nizet
semanticscholar   +1 more source