Results 31 to 40 of about 1,037,757 (288)

Therapeutic Uses of Bacterial Subunit Toxins

Toxins, 2021
The B subunit pentamer verotoxin (VT aka Shiga toxin-Stx) binding to its cellular glycosphingolipid (GSL) receptor, globotriaosyl ceramide (Gb3) mediates internalization and the subsequent receptor mediated retrograde intracellular traffic of the AB5 ...
Clifford Lingwood
doaj   +1 more source

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

, 2021
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Oksana A. Sergeeva, F. Gisou van der Goot, Numa Piot   +2 more
core   +1 more source

Bt Cry1Ab/2Ab toxins disrupt the structure of the gut bacterial community of Locusta migratoria through host immune responses

Ecotoxicology and Environmental Safety, 2022
The gut microbiota of insects plays a vital role in digestion, nutrient acquisition, metabolism of dietary toxins, pathogen immunity and maintenance of gut homeostasis.
Yue Yin, Kaili Cao, Xinxin Zhao, Chuan Cao, Xuehui Dong, Jingang Liang, Wangpeng Shi   +6 more
doaj   +1 more source

Bacterial Toxins

, 2023
Bacterial Toxins.
Brad Bolon, Francisco A. Uzal, Melissa Schutten   +2 more
openaire   +2 more sources

Mechanism of Gene Regulation by a Staphylococcus aureus Toxin

mBio, 2016
The virulence of many bacterial pathogens, including the important human pathogen Staphylococcus aureus, depends on the secretion of frequently large amounts of toxins. Toxin production involves the need for the bacteria to make physiological adjustments
Hwang-Soo Joo, Som S. Chatterjee, Amer E. Villaruz, Seth W. Dickey, Vee Y. Tan, Yan Chen, Daniel E. Sturdevant, Stacy M. Ricklefs, Michael Otto   +8 more
doaj   +1 more source

Antibodies and Vaccines Against Botulinum Toxins: Available Measures and Novel Approaches

, 2019
International audienceBotulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action
Rasetti-Escargueil, Christine, Michel R. Popoff, Popoff, Michel, Christine Rasetti-Escargueil   +3 more
core   +1 more source

Several New Putative Bacterial ADP-Ribosyltransferase Toxins Are Revealed from In Silico Data Mining, Including the Novel Toxin Vorin, Encoded by the Fire Blight Pathogen Erwinia amylovora

, 2020
Mono-ADP-ribosyltransferase (mART) toxins are secreted by several pathogenic bacteria that disrupt vital host cell processes in deadly diseases like cholera and whooping cough.
A. Merrill, Jennifer Geddes-McAlister, Olivier Tremblay, Zachary Thow   +3 more
core   +1 more source

Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin

mBio, 2022
Typhoid toxin is an A2B5 protein toxin and an important virulence factor for the human-adapted bacterial pathogen Salmonella enterica serovar Typhi, the causative agent of typhoid fever. Typhoid toxin contains two enzymatic subunits, PltA and CdtB, which
Xiaoyu Liu, Zhe Chen, Xuyao Jiao, Xukai Jiang, Jicheng Qiu, Fuping You, Hongan Long, Hongzhi Cao, Casey C. Fowler, Xiang Gao   +9 more
doaj   +1 more source

Bacterial Toxins: Friends or Foes?

Emerging Infectious Diseases, 1999
Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes.
Clare K. Schmitt, Karen C. Meysick, Alison D. O'Brien   +2 more
doaj   +1 more source

Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]

, 2009
The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core   +1 more source