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Bacterial Toxins, Current Perspectives [PDF]

Toxins, 2020
Toxins are the major pathogenicity factors produced by numerous bacteria involved in severe diseases in humans and animals. Certain pathogenic bacteria synthesize only one toxin which is responsible for all the symptoms and outcome of the disease.
Michel R. Popoff
doaj   +5 more sources

Clostridial Neurotoxins: Structure, Function and Implications to Other Bacterial Toxins [PDF]

Microorganisms, 2021
Gram-positive bacteria are ancient organisms. Many bacteria, including Gram-positive bacteria, produce toxins to manipulate the host, leading to various diseases. While the targets of Gram-positive bacterial toxins are diverse, many of those toxins use a
Shuowei Cai, Raj Kumar, Bal Ram Singh
doaj   +2 more sources

Special Issue: Gram-Positive Bacterial Toxins [PDF]

Microorganisms, 2023
The Gram stain classifies most bacteria into one of two groups, Gram-negative or Gram-positive, based on the composition of their cell walls [...]
Shashi Sharma, Sabine Pellett, Stephen A. Morse   +2 more
doaj   +2 more sources

Impact of Bacterial Toxins in the Lungs [PDF]

Toxins, 2020
Bacterial toxins play a key role in the pathogenesis of lung disease. Based on their structural and functional properties, they employ various strategies to modulate lung barrier function and to impair host defense in order to promote infection. Although
Rudolf Lucas, Yalda Hadizamani, Joyce Gonzales, Boris Gorshkov, Thomas Bodmer, Yves Berthiaume, Ueli Moehrlen, Hartmut Lode, Hanno Huwer, Martina Hudel, Mobarak Abu Mraheil, Haroldo Alfredo Flores Toque, Trinad Chakraborty, Jürg Hamacher   +13 more
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Some Examples of Bacterial Toxins as Tools [PDF]

Toxins
Pathogenic bacteria produce diverse protein toxins to disturb the host’s defenses. This includes the opening of epithelial barriers to establish bacterial growth in deeper tissues of the host and to modulate immune cell functions.
Gudula Schmidt
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Bacterial Toxins for Cancer Therapy [PDF]

Toxins, 2017
Several pathogenic bacteria secrete toxins to inhibit the immune system of the infected organism. Frequently, they catalyze a covalent modification of specific proteins. Thereby, they block production and/or secretion of antibodies or cytokines. Moreover,
Nour-Imene Zahaf, Gudula Schmidt
doaj   +2 more sources

Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?

Toxins, 2015
Autophagy is a physiological process involved in defense mechanisms for clearing intracellular bacteria. The autophagic pathway is finely regulated and bacterial toxins interact with this process in a complex manner.
Jacques Mathieu
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Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
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Regulatory Networks Controlling Neurotoxin Synthesis in Clostridium botulinum and Clostridium tetani

Toxins, 2022
Clostridium botulinum and Clostridium tetani are Gram-positive, spore-forming, and anaerobic bacteria that produce the most potent neurotoxins, botulinum toxin (BoNT) and tetanus toxin (TeNT), responsible for flaccid and spastic paralysis, respectively ...
Michel R. Popoff, Holger Brüggemann
doaj   +1 more source

Anaerobes and Toxins, a Tradition of the Institut Pasteur

Toxins, 2023
Louis Pasteur, one of the eminent pioneers of microbiology, discovered life without oxygen and identified the first anaerobic pathogenic bacterium. Certain bacteria were found to be responsible for specific diseases.
Michel R. Popoff, Sandra Legout
doaj   +1 more source