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Toxin-antitoxins and bacterial virulence [PDF]

FEMS Microbiology Reviews, 2016
Bacterial virulence relies on a delicate balance of signals interchanged between the invading microbe and the host. This communication has been extensively perceived as a battle involving harmful molecules produced by the pathogen and host defenses. In this review, we focus on a largely unexplored element of this dialogue, as are toxin-antitoxin (TA ...
Damián Lobato-Márquez, Francisco García-del Portillo   +1 more
exaly   +4 more sources

Emerging Roles of Toxin-Antitoxin Modules in Bacterial Pathogenesis

Molecules, 2016
Toxin-antitoxin (TA) cassettes are encoded widely by bacteria. The modules typically comprise a protein toxin and protein or RNA antitoxin that sequesters the toxin factor.
Barbara Kędzierska, Finbarr Hayes
exaly   +3 more sources

Gaining New Insights into Fundamental Biological Pathways by Bacterial Toxin-Based Genetic Screens [PDF]

Bioengineering, 2023
Songhai Tian, Nini Zhou
exaly   +2 more sources

A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence [PDF]

MBio, 2021
Xiaofeng Zhou, Lucy Shapiro
exaly   +2 more sources

Susceptibility of hamsters to clostridium difficile isolates of differing toxinotype [PDF]

, 2013
Clostridium difficile is the most commonly associated cause of antibiotic associated disease (AAD), which caused ~21,000 cases of AAD in 2011 in the U.K. alone.
A Buckley, Anthony M. Buckley, B Elliott, C Rousseau, C Schwan, D Drudy, D Goulding, D Lyras, Denise Candlish, DM Guerrero, F Miyajima, Gillian R. Douce, H Huang, H Kim, H Kim, I Duerden, I Vesteinsdottir, J Andrews, J Kim, J Ng, J Pépin, J Wang, Janice Spencer, JG Bartlett, JM Lanis, June J. Irvine, JW Marsh, LA Petrella, Lindsay M. Maclellan, LJ Deakin, M Arvand, M He, M Merrigan, M Rupnik, MH Wilcox, MH Wilcox, Michel R. Popoff, MM Nerandzic, MSM Brouwer, N Razaq, N Stoesser, P Vohra, R Stabler, R Stabler, S Kamiya, S Kuehne, SA Villano, SP Sambol, SP Sambol, ST Cartman, TS Steiner, V Braun, V Casas, Y Ogura   +53 more
core   +18 more sources

Bacillus thuringiensis Cry4Ba Insecticidal ToxinExploits Leu⁶¹⁵ in Its C-Terminal Domain to Interact with a Target Receptor—Aedes aegypti Membrane-Bound Alkaline Phosphatase

Toxins, 2021
In addition to the receptor-binding domain (DII), the C-terminal domain (DIII) of three-domain Cry insecticidal δ-endotoxins from Bacillus thuringiensis has been implicated in target insect specificity, yet its precise mechanistic role remains unclear ...
Anon Thammasittirong, Sutticha Na-Ranong Thammasittirong, Chompounoot Imtong, Sathapat Charoenjotivadhanakul, Somsri Sakdee, Hui-Chun Li, Siriporn Okonogi, Chanan Angsuthanasombat   +7 more
doaj   +1 more source

Cry4Aa and Cry4Ba Mosquito-Active Toxins Utilize Different Domains in Binding to a Particular Culex ALP Isoform: A Functional Toxin Receptor Implicating Differential Actions on Target Larvae

Toxins, 2022
The three-domain Cry4Aa toxin produced from Bacillus thuringiensis subsp. israelensis was previously shown to be much more toxic to Culex mosquito larvae than its closely related toxin—Cry4Ba.
Manussawee Dechkla, Sathapat Charoenjotivadhanakul, Chompounoot Imtong, Sarinporn Visitsattapongse, Hui-Chun Li, Chanan Angsuthanasombat   +5 more
doaj   +1 more source

Surface proteins of Shiga toxin-producing Escherichia coli mediate association with milk fat globules in raw milk

Frontiers in Microbiology, 2023
IntroductionBy adhering to host cells and colonizing tissues, bacterial pathogens can successfully establish infection. Adhesion is considered the first step of the infection process and bacterial adhesion to anti-adhesive compounds is now seen as a ...
Arthur Bagel, Marion Bouvier-Crozier, Marion Bouvier-Crozier, Mélissa Canizares, Badis Hamadou, Louise Courcol, Christelle Lopez, Valérie Michel, Thomas Douellou, Delphine Sergentet, Delphine Sergentet   +10 more
doaj   +1 more source

Comparison of Two Shiga Toxin-producing Escherichia coli (STEC) Isolation Protocols in Raw Cow’s Milk Cheese Enrichment Broths: Direct STEC Isolation Versus Techniques Based on Immuno-concentration

Journal of Food Protection, 2023
The presence of Shiga toxin-producing Escherichia coli (STEC) in dairy products made with raw milk is a major concern for food safety authorities and industries. Two approaches have been proposed to isolate STEC from food.
Stephane D. Miszczycha, Christine Mazuy-Cruchaudet, Camille Thollet, Delphine Sergentet-Thevenot   +3 more
doaj   +1 more source

Intracellular Localization of the Proteins Encoded by Some Type II Toxin-Antitoxin Systems in Escherichia coli

mBio, 2021
Bacterial toxin-antitoxin (TA) systems encode a toxin and an antitoxin that counteracts the toxin. Such TA systems are found abundantly on bacterial chromosomes and on extrachromosomal genetic elements. The toxin is always a protein.
Alexander Mager, Tommy Safran, Hanna Engelberg-Kulka   +2 more
doaj   +1 more source